Uploaded January 2024 | Updated September 2026, 1 week ago
In this video, I spoke with Aaron King who recently built AgeRank, a tool that shows how various biomarkers change with age. From here we discuss the use-case of biological age, the implications of aging research, and the possibility of reversing aging in the future.
AgeRank - agerank.com
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Timestamps:
Intro - 00:00
AgeRank - 00:36
Biological Age - 14:20
Bryan Johnson - 17:45
Reversing Aging - 23:00
Germline - 28:00
Knowledge collection - 37:30
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
In this video, I spoke with Aaron King who recently built AgeRank, a tool that shows how various biomarkers change with age. From here we discuss the use-case of biological age, the implications of aging research, and the possibility of reversing aging in the future.
AgeRank - agerank.com
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Timestamps:
Intro - 00:00
AgeRank - 00:36
Biological Age - 14:20
Bryan Johnson - 17:45
Reversing Aging - 23:00
Germline - 28:00
Knowledge collection - 37:30
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.









![The potential of fasting to delay aging (Periodic vs. intermittent)
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesnt overlap with anti-aging supplements.
*Get 10% off at DoNotAge using my discount code SHEEKEY*
http://bit.ly/DoNotAgeProducts
DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
*The patreon is launched* If you want to support the channel/get extra access to video drawing maps and behind the scenes updates check it out.
https://www.patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). https://doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - https://doi.org/10.1016/j.cmet.2016.06.001
TRF study - https://doi.org/10.1016/j.cmet.2012.04.019
FMD study - https://doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com The potential of fasting to delay aging (Periodic vs. intermittent)](https://i.ytimg.com/vi/y4CRQTpDJI0/mqdefault.jpg)
