Uploaded January 2022 | Updated September 2026, 1 week ago
57-year old David Bennett received a heart transplant this week from a genetically modified pig. So, this raises Three questions. Why, how, what now?
There is currently a huge shortage for organ transplants. 17 people in the US die every day waiting for a transplant and there are over 100,00 apparently waiting. And this number is only expected to grow in the future as the population increases and gets older.
So what are the options
- xenotransplantation & genetic engineering (gene editing)
- stem cells & cellular reprogramming
- mechanically enhanced organs
But what ethical considerations come along with these strategies?
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
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Timestamps:
Why pigs? - 00:00
How - gene editing? - 01:40
What now - ethics & other options - 03:40
References:
bbc.co.uk/news/world-59951264
Here’s how scientists pulled off the first pig-to-human heart transplant - science.org/content/article/here-s-how-scientists-pulled-first-pig-human-heart-transplant
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
57-year old David Bennett received a heart transplant this week from a genetically modified pig. So, this raises Three questions. Why, how, what now?
There is currently a huge shortage for organ transplants. 17 people in the US die every day waiting for a transplant and there are over 100,00 apparently waiting. And this number is only expected to grow in the future as the population increases and gets older.
So what are the options
- xenotransplantation & genetic engineering (gene editing)
- stem cells & cellular reprogramming
- mechanically enhanced organs
But what ethical considerations come along with these strategies?
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Timestamps:
Why pigs? - 00:00
How - gene editing? - 01:40
What now - ethics & other options - 03:40
References:
bbc.co.uk/news/world-59951264
Here’s how scientists pulled off the first pig-to-human heart transplant - science.org/content/article/here-s-how-scientists-pulled-first-pig-human-heart-transplant
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com


![The potential of fasting to delay aging (Periodic vs. intermittent)
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesnt overlap with anti-aging supplements.
*Get 10% off at DoNotAge using my discount code SHEEKEY*
http://bit.ly/DoNotAgeProducts
DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
*The patreon is launched* If you want to support the channel/get extra access to video drawing maps and behind the scenes updates check it out.
https://www.patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). https://doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - https://doi.org/10.1016/j.cmet.2016.06.001
TRF study - https://doi.org/10.1016/j.cmet.2012.04.019
FMD study - https://doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com The potential of fasting to delay aging (Periodic vs. intermittent)](https://i.ytimg.com/vi/y4CRQTpDJI0/mqdefault.jpg)





