Uploaded March 2023 | Updated September 2026, 1 week ago
There’s a phrase that get’s thrown around a lot these days, particularly in the longevity space. And that phrase is Sheekey Science. But there’s another word you may also hear about and that is epigenetic reprogramming. I am guilty myself of throwing this word around without really explaining what i mean by this. I’ve discussed reprogramming before, but i want to discuss in this video what is really meant by the phrase epigenetics, as And it goes beyond me, do you really know what they means by that term. Well, by the end of this video, you will have my interpretation of the term which has come from the science literature that i;ve read, and for fun, i’ll throw in other scientists definitions too.
In particular i will focus mainly on the link between epigenetics, gene expression and cell identity - what makes a happy healthy cell do what it does best. And i think by the end of it you will have 3 main take homes;
(i) an appreciation of genome organisation & cell identity - with some shocking surprises
(ii) an overview of the different classes of epigenetics
(iii) modern day & epigenetic reprogramming
TIMESTAMPS:
Intro - 00:00
DNA packing & chromatin organisation - 01:05
Histone marks - 05:15
DNA methylation - 06:20
RNA - 07:57
Epigenetic reprogramming - 09:45
References:
asheekeyscienceblogcom.wordpress.com/2017/09/13/time-to-re-write-the-textbooks-how-dna-is-really-packed-inside-the-nucleus
Holoch, D., Moazed, D. RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet 16, 71–84 (2015). doi.org/10.1038/nrg3863
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
There’s a phrase that get’s thrown around a lot these days, particularly in the longevity space. And that phrase is Sheekey Science. But there’s another word you may also hear about and that is epigenetic reprogramming. I am guilty myself of throwing this word around without really explaining what i mean by this. I’ve discussed reprogramming before, but i want to discuss in this video what is really meant by the phrase epigenetics, as And it goes beyond me, do you really know what they means by that term. Well, by the end of this video, you will have my interpretation of the term which has come from the science literature that i;ve read, and for fun, i’ll throw in other scientists definitions too.
In particular i will focus mainly on the link between epigenetics, gene expression and cell identity - what makes a happy healthy cell do what it does best. And i think by the end of it you will have 3 main take homes;
(i) an appreciation of genome organisation & cell identity - with some shocking surprises
(ii) an overview of the different classes of epigenetics
(iii) modern day & epigenetic reprogramming
TIMESTAMPS:
Intro - 00:00
DNA packing & chromatin organisation - 01:05
Histone marks - 05:15
DNA methylation - 06:20
RNA - 07:57
Epigenetic reprogramming - 09:45
References:
asheekeyscienceblogcom.wordpress.com/2017/09/13/time-to-re-write-the-textbooks-how-dna-is-really-packed-inside-the-nucleus
Holoch, D., Moazed, D. RNA-mediated epigenetic regulation of gene expression. Nat Rev Genet 16, 71–84 (2015). doi.org/10.1038/nrg3863
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
