Uploaded January 2021 | Updated September 2026, 1 week ago
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesn't overlap with anti-aging supplements.
*Get 10% off at DoNotAge using my discount code "SHEEKEY"*
bit.ly/DoNotAgeProducts
DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
*The patreon is launched* If you want to support the channel/get extra access to video drawing maps and behind the scenes updates check it out.
patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - doi.org/10.1016/j.cmet.2016.06.001
TRF study - doi.org/10.1016/j.cmet.2012.04.019
FMD study - doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesn't overlap with anti-aging supplements.
*Get 10% off at DoNotAge using my discount code "SHEEKEY"*
bit.ly/DoNotAgeProducts
DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
*The patreon is launched* If you want to support the channel/get extra access to video drawing maps and behind the scenes updates check it out.
patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - doi.org/10.1016/j.cmet.2016.06.001
TRF study - doi.org/10.1016/j.cmet.2012.04.019
FMD study - doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
