Uploaded December 2024 | Updated September 2026, 1 week ago
Every year I compile what I think were some important contributions to longevity research. Here is my list for 2024!
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro - 00:00
Stem cells - 00:30
Skin - 04:30
Reproduction and fertility - 05:30
What is aging? - 07:45
Immune response - 10:00
Lifespan extension - 12:30
References
Disagreement on foundational principles of biological aging, PNAS Nexus, Volume 3, Issue 12, December 2024, pgae499, doi.org/10.1093/pnasnexus/pgae499
Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging 4, 1619–1634 (2024). doi.org/10.1038/s43587-024-00692-2
Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). doi.org/10.1038/s41586-024-07701-9
Olshansky, S.J., Willcox, B.J., Demetrius, L. et al. Implausibility of radical life extension in humans in the twenty-first century. Nat Aging 4, 1635–1642 (2024). doi.org/10.1038/s43587-024-00702-3
Miller, R.A., Harrison, D.E., Cortopassi, G.A. et al. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. GeroScience 46, 4657–4670 (2024). doi.org/10.1007/s11357-024-01176-2
Qu, Q., Chen, Y., Wang, Y. et al. Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature (2024). doi.org/10.1038/s41586-024-08329-5
Ross, J.B., Myers, L.M., Noh, J.J. et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature 628, 162–170 (2024). doi.org/10.1038/s41586-024-07238-x
Wang, H., Huang, Z., Shen, X. et al. Rejuvenation of aged oocyte through exposure to young follicular microenvironment. Nat Aging 4, 1194–1210 (2024). doi.org/10.1038/s43587-024-00697-x
Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan
Soma, Takeshi et al.
The Lancet, Volume 404, Issue 10466, 1929 - 1939 thelancet.com/journals/lancet/article/PIIS0140-6736(24)01764-1/fulltext
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient doi.org/10.1016/j.cell.2024.09.004
The use of ectopic volar fibroblasts to modify skin identity - doi.org/10.1126/science.adi1650
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline - cell.com/cell-metabolism/abstract/S1550-4131(24)00015-9
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging doi.org/10.1016/j.cell.2024.10.019
Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Every year I compile what I think were some important contributions to longevity research. Here is my list for 2024!
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro - 00:00
Stem cells - 00:30
Skin - 04:30
Reproduction and fertility - 05:30
What is aging? - 07:45
Immune response - 10:00
Lifespan extension - 12:30
References
Disagreement on foundational principles of biological aging, PNAS Nexus, Volume 3, Issue 12, December 2024, pgae499, doi.org/10.1093/pnasnexus/pgae499
Shen, X., Wang, C., Zhou, X. et al. Nonlinear dynamics of multi-omics profiles during human aging. Nat Aging 4, 1619–1634 (2024). doi.org/10.1038/s43587-024-00692-2
Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). doi.org/10.1038/s41586-024-07701-9
Olshansky, S.J., Willcox, B.J., Demetrius, L. et al. Implausibility of radical life extension in humans in the twenty-first century. Nat Aging 4, 1635–1642 (2024). doi.org/10.1038/s43587-024-00702-3
Miller, R.A., Harrison, D.E., Cortopassi, G.A. et al. Lifespan effects in male UM-HET3 mice treated with sodium thiosulfate, 16-hydroxyestriol, and late-start canagliflozin. GeroScience 46, 4657–4670 (2024). doi.org/10.1007/s11357-024-01176-2
Qu, Q., Chen, Y., Wang, Y. et al. Lithocholic acid phenocopies anti-ageing effects of calorie restriction. Nature (2024). doi.org/10.1038/s41586-024-08329-5
Ross, J.B., Myers, L.M., Noh, J.J. et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature 628, 162–170 (2024). doi.org/10.1038/s41586-024-07238-x
Wang, H., Huang, Z., Shen, X. et al. Rejuvenation of aged oocyte through exposure to young follicular microenvironment. Nat Aging 4, 1194–1210 (2024). doi.org/10.1038/s43587-024-00697-x
Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan
Soma, Takeshi et al.
The Lancet, Volume 404, Issue 10466, 1929 - 1939 thelancet.com/journals/lancet/article/PIIS0140-6736(24)01764-1/fulltext
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient doi.org/10.1016/j.cell.2024.09.004
The use of ectopic volar fibroblasts to modify skin identity - doi.org/10.1126/science.adi1650
IgG is an aging factor that drives adipose tissue fibrosis and metabolic decline - cell.com/cell-metabolism/abstract/S1550-4131(24)00015-9
Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging doi.org/10.1016/j.cell.2024.10.019
Please note that the information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
