Uploaded September 2021 | Updated September 2026, 1 week ago
This is part of a full-length interview I had with Prof Brian Kennedy - youtu.be/iYO-j2hesRw
Here we discuss aging biomarkers and what are currently being used in clinical trials to evaluate the efficacy of different anti-aging interventions and longevity therapeutics. The idea is to measure biological age before, during and after interventions. We touch on epigenetic clocks and facial aging approaches.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
This is part of a full-length interview I had with Prof Brian Kennedy - youtu.be/iYO-j2hesRw
Here we discuss aging biomarkers and what are currently being used in clinical trials to evaluate the efficacy of different anti-aging interventions and longevity therapeutics. The idea is to measure biological age before, during and after interventions. We touch on epigenetic clocks and facial aging approaches.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com

![The potential of fasting to delay aging (Periodic vs. intermittent)
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesnt overlap with anti-aging supplements.
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TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). https://doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - https://doi.org/10.1016/j.cmet.2016.06.001
TRF study - https://doi.org/10.1016/j.cmet.2012.04.019
FMD study - https://doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com The potential of fasting to delay aging (Periodic vs. intermittent)](https://i.ytimg.com/vi/y4CRQTpDJI0/mqdefault.jpg)





