Uploaded October 2022 | Updated September 2026, 1 week ago
Food. We need it to survive. So maybe it's not surprising that many fix there daily routine and work schedule around it. While many like to discuss the quantity and quality of your diet, one factor i also think is important is when. So given some recent randomized controlled crossover trial looked into this, i thought it was time to talk about time in food consumption. They all seem to reach the same conclusion; so let’s take a quick look through them to see what, address the limitations and discuss what this all means. But firstly, why might timing of food consumption be important?
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TIMESTAMPS:
Intro - 00:00
Circadian Rhythms - 00:45
Studies - 04:30
Discussion - 08:35
References:
Takahashi, J. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet 18, 164–179 (2017). doi.org/10.1038/nrg.2016.150
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity - doi.org/10.1016/j.cmet.2022.09.007
Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity - doi.org/10.1016/j.cmet.2022.08.001
Xie, Z., Sun, Y., Ye, Y. et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun 13, 1003 (2022). doi.org/10.1038/s41467-022-28662-5
Circadian Integration of Metabolism and Energetics - doi.org/10.1126/science.1195027
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Food. We need it to survive. So maybe it's not surprising that many fix there daily routine and work schedule around it. While many like to discuss the quantity and quality of your diet, one factor i also think is important is when. So given some recent randomized controlled crossover trial looked into this, i thought it was time to talk about time in food consumption. They all seem to reach the same conclusion; so let’s take a quick look through them to see what, address the limitations and discuss what this all means. But firstly, why might timing of food consumption be important?
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Circadian Rhythms - 00:45
Studies - 04:30
Discussion - 08:35
References:
Takahashi, J. Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet 18, 164–179 (2017). doi.org/10.1038/nrg.2016.150
Late isocaloric eating increases hunger, decreases energy expenditure, and modifies metabolic pathways in adults with overweight and obesity - doi.org/10.1016/j.cmet.2022.09.007
Timing of daily calorie loading affects appetite and hunger responses without changes in energy metabolism in healthy subjects with obesity - doi.org/10.1016/j.cmet.2022.08.001
Xie, Z., Sun, Y., Ye, Y. et al. Randomized controlled trial for time-restricted eating in healthy volunteers without obesity. Nat Commun 13, 1003 (2022). doi.org/10.1038/s41467-022-28662-5
Circadian Integration of Metabolism and Energetics - doi.org/10.1126/science.1195027
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com








![The potential of fasting to delay aging (Periodic vs. intermittent)
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesnt overlap with anti-aging supplements.
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DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
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https://www.patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). https://doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - https://doi.org/10.1016/j.cmet.2016.06.001
TRF study - https://doi.org/10.1016/j.cmet.2012.04.019
FMD study - https://doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com The potential of fasting to delay aging (Periodic vs. intermittent)](https://i.ytimg.com/vi/y4CRQTpDJI0/mqdefault.jpg)

