Uploaded November 2021 | Updated September 2026, 1 week ago
Sleep is a non-negotiable biological state required for the maintenance of human life. Much like how we need water, food, oxygen, we also need sleep. But why, what happens when we sleep, what is good sleep health and what strategies can be employed to achieve this? Well, hello and welcome to The Sheekey Science Show where we will discuss all 3 of these questions in this weeks video. Why, because it is interesting of course, but also because, many reviews came out in science last week, or the week before, on the topic and I thought I’d share some of the interesting points from them. For example we will talk about the importance of memory consolidation and waste clearance (such as amyloid beta and tau) from the brain during sleep. And then bonus, at the end, I’ll share some tips that help me sleep.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
What is sleep - 00:45
Memory consolidation - 01:30
Waste clearance - 04:00
6 dimensions of sleep health - 05:45
Sleep technology - 07:45
Other tips for good sleep - 10:45
REFERENCES:
The interconnected causes and consequences of sleep in the brain - doi.org/10.1126/science.abi8375
Marshall, L., Helgadóttir, H., Mölle, M. et al. Boosting slow oscillations during sleep potentiates memory. Nature 444, 610–613 (2006). doi.org/10.1038/nature05278
The translational neuroscience of sleep: A contextual framework - doi.org/10.1126/science.abj8188
Brain neural patterns and the memory function of sleep - doi.org/10.1126/science.abi8370
Orthosomnia: Are Some Patients Taking the Quantified Self Too Far? - doi.org/10.5664/jcsm.6472
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Sleep is a non-negotiable biological state required for the maintenance of human life. Much like how we need water, food, oxygen, we also need sleep. But why, what happens when we sleep, what is good sleep health and what strategies can be employed to achieve this? Well, hello and welcome to The Sheekey Science Show where we will discuss all 3 of these questions in this weeks video. Why, because it is interesting of course, but also because, many reviews came out in science last week, or the week before, on the topic and I thought I’d share some of the interesting points from them. For example we will talk about the importance of memory consolidation and waste clearance (such as amyloid beta and tau) from the brain during sleep. And then bonus, at the end, I’ll share some tips that help me sleep.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
What is sleep - 00:45
Memory consolidation - 01:30
Waste clearance - 04:00
6 dimensions of sleep health - 05:45
Sleep technology - 07:45
Other tips for good sleep - 10:45
REFERENCES:
The interconnected causes and consequences of sleep in the brain - doi.org/10.1126/science.abi8375
Marshall, L., Helgadóttir, H., Mölle, M. et al. Boosting slow oscillations during sleep potentiates memory. Nature 444, 610–613 (2006). doi.org/10.1038/nature05278
The translational neuroscience of sleep: A contextual framework - doi.org/10.1126/science.abj8188
Brain neural patterns and the memory function of sleep - doi.org/10.1126/science.abi8370
Orthosomnia: Are Some Patients Taking the Quantified Self Too Far? - doi.org/10.5664/jcsm.6472
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com



![The potential of fasting to delay aging (Periodic vs. intermittent)
In this video I discuss different types of fasting diets (both periodic and intermittent) and the underlying molecular mechanisms and why they have potential to delay aging and aging-related diseases. In particular we will address the importance of refeeding, which is more intense in periodic fasting (and fast mimicking diets [FMD]) due to the more severe fasting length, and activation of stem cells for regeneration & rejuvenation of tissues. We will also discuss the pros and concerns for fasting and how fasting overlaps or doesnt overlap with anti-aging supplements.
*Get 10% off at DoNotAge using my discount code SHEEKEY*
http://bit.ly/DoNotAgeProducts
DoNotAge are supporting my channel in the education of longevity and aging research. They also sell a variety of supplements including NMN, resveratrol, fisetin and more! :)
Disclaimer - using this discount will provide the channel with a small commission, so only use if you want to support the channel! :)
*The patreon is launched* If you want to support the channel/get extra access to video drawing maps and behind the scenes updates check it out.
https://www.patreon.com/TheSheekeyScienceShow
TIMESTAMPS;
Intro - 0:00
Fasting diets - 01:10
Fasting mechanisms - 03:10
Longevity signalling - 04:30
Intermittent fasting pros & cons - 06:55
Periodic fasting - 10:15
Refeeding importance - 11:50
Supplements & fasting - 13:30
Which is better IF vs. PF? - 14:40
Other questions - 15:25
References;
Longo, V.D., Di Tano, M., Mattson, M.P. et al. Intermittent and periodic fasting, longevity and disease. Nat Aging 1, 47–59 (2021). https://doi.org/10.1038/s43587-020-00013-3
Panda & Longo review article - https://doi.org/10.1016/j.cmet.2016.06.001
TRF study - https://doi.org/10.1016/j.cmet.2012.04.019
FMD study - https://doi.org/10.1016/j.cmet.2015.05.012
Icons in intro; https://www.freepik.com/free-photos-vectors/backgroundBackground vector created by freepik - www.freepik.com The potential of fasting to delay aging (Periodic vs. intermittent)](https://i.ytimg.com/vi/y4CRQTpDJI0/mqdefault.jpg)





