Uploaded December 2021 | Updated September 2026, 2 weeks ago
“Remarkably, individuals showed an average decrease in biological aging of 8 years”
This week in the journal Aging-US, we get a look at the first data of Rejuvant, an alpha ketoglutarate (AKG) based formulation, in human patients.
It was previously shown in a study that AKG supplementation increases the lifespan of the worms C.elegans and I reported on the study that came out last year showing that the calcium-salt of AKG extended both the lifespan and healthspan of mice.
In this publication they show 42 participants take Rejuvant and used DNA methylation (epigenetic age) to assess their "biological age". The data shows it conferred an average 8 year reduction in biological aging, after an average of 7 months of use. In this video we will break down this paper completely, address exactly what the data shows, what it doesn’t show and what I think the take homes are? We'll also discuss the limitations such as lack of clinical markers and no placebo group!!
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Alpha ketoglutarate - 00:30
Human data & age reversal - 1:30
Limitations - what you must know - 05:30
REFERENCES:
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021; 13:24485-24499. doi.org/10.18632/aging.203736
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
“Remarkably, individuals showed an average decrease in biological aging of 8 years”
This week in the journal Aging-US, we get a look at the first data of Rejuvant, an alpha ketoglutarate (AKG) based formulation, in human patients.
It was previously shown in a study that AKG supplementation increases the lifespan of the worms C.elegans and I reported on the study that came out last year showing that the calcium-salt of AKG extended both the lifespan and healthspan of mice.
In this publication they show 42 participants take Rejuvant and used DNA methylation (epigenetic age) to assess their "biological age". The data shows it conferred an average 8 year reduction in biological aging, after an average of 7 months of use. In this video we will break down this paper completely, address exactly what the data shows, what it doesn’t show and what I think the take homes are? We'll also discuss the limitations such as lack of clinical markers and no placebo group!!
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Alpha ketoglutarate - 00:30
Human data & age reversal - 1:30
Limitations - what you must know - 05:30
REFERENCES:
Demidenko O, Barardo D, Budovskii V, Finnemore R, Palmer FR, Kennedy BK, Budovskaya YV. Rejuvant®, a potential life-extending compound formulation with alpha-ketoglutarate and vitamins, conferred an average 8 year reduction in biological aging, after an average of 7 months of use, in the TruAge DNA methylation test. Aging (Albany NY). 2021; 13:24485-24499. doi.org/10.18632/aging.203736
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
