Uploaded September 2025 | Updated September 2026, 3 weeks ago
In this exclusive interview, I sit down with Rico Meinl, Head of Applied AI at Retro Biosciences, to discuss their groundbreaking collaboration with OpenAI. They've successfully used GPT-4b micro to redesign Yamanaka factors - achieving 50x more efficient cellular reprogramming than nature's original design.
🔬 Key Breakthrough:
Retro's AI-designed proteins (Retro-Sox2 and Retro-Klf4) showed unprecedented efficiency in converting adult cells back into stem cells, with potential applications in regenerative medicine and aging reversal.
This represents a paradigm shift from incremental protein modifications to massive redesigns that work better than millions of years of evolution.
openai.com/index/accelerating-life-sciences-research-with-retro-biosciences
TIMESTAMPS
00:52 - Company Introduction & Mission
03:28 - OpenAI Collaboration Background
12:04 - Protein Design Process
17:49 - 50x Efficiency Results
27:30 - Clinical Applications & Timeline
31:46 - Future of AI in Biology
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
In this exclusive interview, I sit down with Rico Meinl, Head of Applied AI at Retro Biosciences, to discuss their groundbreaking collaboration with OpenAI. They've successfully used GPT-4b micro to redesign Yamanaka factors - achieving 50x more efficient cellular reprogramming than nature's original design.
🔬 Key Breakthrough:
Retro's AI-designed proteins (Retro-Sox2 and Retro-Klf4) showed unprecedented efficiency in converting adult cells back into stem cells, with potential applications in regenerative medicine and aging reversal.
This represents a paradigm shift from incremental protein modifications to massive redesigns that work better than millions of years of evolution.
openai.com/index/accelerating-life-sciences-research-with-retro-biosciences
TIMESTAMPS
00:52 - Company Introduction & Mission
03:28 - OpenAI Collaboration Background
12:04 - Protein Design Process
17:49 - 50x Efficiency Results
27:30 - Clinical Applications & Timeline
31:46 - Future of AI in Biology
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
