Uploaded April 2026 | Updated September 2026, 3 weeks ago
In this episode , I speak with Peter Fedichev, co-founder and CEO of Gero, about whether aging can be understood through just three variables: stress, damage, and noise. He explains why many current longevity interventions may only be “level 1” therapies, why mice and humans may age in fundamentally different ways, and what it could take to push human lifespan beyond its current apparent limit.
Find me on Twitter - twitter.com/EleanorSheekey
official website - thesheekeyscienceshow.com
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
0:00 – Aging as a 3-variable system: why aging may be better understood through a minimal model rather than a huge list of hallmarks.
12:58 – Stress, damage, and noise: the three factors Peter says shape aging trajectories.
22:36 – Why mice and humans age differently: stable vs unstable species.
34:36 – Can damaged tissues really be replaced to reverse aging?
44:32 – Effective temperature, physiological noise, and level 2 interventions.
57:02 – How AI could speed up drug discovery
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
In this episode , I speak with Peter Fedichev, co-founder and CEO of Gero, about whether aging can be understood through just three variables: stress, damage, and noise. He explains why many current longevity interventions may only be “level 1” therapies, why mice and humans may age in fundamentally different ways, and what it could take to push human lifespan beyond its current apparent limit.
Find me on Twitter - twitter.com/EleanorSheekey
official website - thesheekeyscienceshow.com
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
0:00 – Aging as a 3-variable system: why aging may be better understood through a minimal model rather than a huge list of hallmarks.
12:58 – Stress, damage, and noise: the three factors Peter says shape aging trajectories.
22:36 – Why mice and humans age differently: stable vs unstable species.
34:36 – Can damaged tissues really be replaced to reverse aging?
44:32 – Effective temperature, physiological noise, and level 2 interventions.
57:02 – How AI could speed up drug discovery
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
