Uploaded July 2026 | Updated September 2026, 3 weeks ago

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Researchers at Revel Pharmaceuticals and Calico Life Sciences have engineered CMLase, an enzyme that removes carboxymethyl-lysine (CML) — a glycation product long considered permanent damage on our longest-lived proteins. In this video I explain the details behind this discovery and what it means for the aging field.

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TIMESTAMPS
0:00 – Intro: what CML is and why it seemed irreversible
2:25 – How they made the enzyme
6:20 – Human tissue data
7:40 – My thoughts and limitations

Paper: Trabosh et al., Nature Communications, 2026 — doi.org/10.1038/s41467-026-75141-2

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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