Uploaded June 2025 | Updated September 2026, 3 weeks ago

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What if reversing cellular aging could be achieved by overexpressing just a single gene? In this video, I break down Shift Bioscience’s latest preprint, which claims that their novel gene, SB000, can safely rejuvenate cells across multiple cell types—without the risks associated with traditional Yamanaka factors.

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00:00 – The bold claim: Can one gene rejuvenate a cell?
01:36 – Shift’s preprint
06:46 – Limitations, unknowns, and next steps for clinical translation

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's academic teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.