Uploaded December 2021 | Updated September 2026, 3 weeks ago
The presence of senescent cells has been shown to increase with age and may even be causal for some aspects of aging. Senolytics selectively kill senescent cells. But many current senolytic drugs (fisetin, quercetin, PCC1) are likely to have some impact on healthy cells.
A new study has proposed a senolytic vaccine that targets cells expressing the membrane protein Gpnmb.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Senolytics - 00:30
Vaccine - 2:00
A vaccine for aging? - 4:25
REFERENCES:
Suda, M., Shimizu, I., Katsuumi, G. et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging 1, 1117–1126 (2021). doi.org/10.1038/s43587-021-00151-2
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
The presence of senescent cells has been shown to increase with age and may even be causal for some aspects of aging. Senolytics selectively kill senescent cells. But many current senolytic drugs (fisetin, quercetin, PCC1) are likely to have some impact on healthy cells.
A new study has proposed a senolytic vaccine that targets cells expressing the membrane protein Gpnmb.
Find me on Twitter - twitter.com/EleanorSheekey
I have Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Senolytics - 00:30
Vaccine - 2:00
A vaccine for aging? - 4:25
REFERENCES:
Suda, M., Shimizu, I., Katsuumi, G. et al. Senolytic vaccination improves normal and pathological age-related phenotypes and increases lifespan in progeroid mice. Nat Aging 1, 1117–1126 (2021). doi.org/10.1038/s43587-021-00151-2
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
