Uploaded January 2023 | Updated September 2026, 2 weeks ago
Aging. It’s what we do. And what i’m here to talk about today. In particular, addressing a recent paper that claims to test the information theory of aging that has come out from David Sinclair’s lab at Harvard Medical School and claims to drive aging both forwards and backwards.
In this paper they generate a mouse model (ICE-mice) where additional DNA damage can be controlled to induce, they hope, epigenetic changes to test their theory that loss of epigenetic information drives aging. Let's find out.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
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TIMESTAMPS
Intro - 00:00
Information theory of aging - 00:45
The results - 05:00
The thoughts - 10:45
References:
Loss of epigenetic information as a cause of mammalian aging - doi.org/10.1016/j.cell.2022.12.027
science.org/content/article/two-research-teams-reverse-signs-aging-mice
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
Aging. It’s what we do. And what i’m here to talk about today. In particular, addressing a recent paper that claims to test the information theory of aging that has come out from David Sinclair’s lab at Harvard Medical School and claims to drive aging both forwards and backwards.
In this paper they generate a mouse model (ICE-mice) where additional DNA damage can be controlled to induce, they hope, epigenetic changes to test their theory that loss of epigenetic information drives aging. Let's find out.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro - 00:00
Information theory of aging - 00:45
The results - 05:00
The thoughts - 10:45
References:
Loss of epigenetic information as a cause of mammalian aging - doi.org/10.1016/j.cell.2022.12.027
science.org/content/article/two-research-teams-reverse-signs-aging-mice
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
