Uploaded March 2026 | Updated September 2026, 2 weeks ago

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Dr. Rhonda Patrick and Dr. Andrew Huberman discuss the multifaceted benefits of creatine for muscle and brain health, highlighting how dosages of 10 to 20 grams may be required to overcome the blood-brain barrier and support cognitive performance during periods of sleep deprivation or age-related decline.

Dr. Rhonda Patrick, PhD, is a biomedical scientist and public science educator. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.

Watch the full episode: youtu.be/C0DMdUqF73Q?si=tnyaZmroMt6vC7Zi
Show notes: go.hubermanlab.com/h6uw5eR

*Timestamps*
00:00 Creatine Use
01:43 Loading Phase Explained
04:29 Emerging Cognitive Benefits Research
07:04 Optimal Dosage for Brain Function
07:54 Creatine for Sleep Deprivation
12:23 Aging & Cognitive Performance
14:19 Neuroplasticity & Lifelong Learning
16:26 Future Studies & Safety

#HubermanLab #RhondaPatrick

Disclaimer & Disclosures: hubermanlab.com/disclaimer