Uploaded August 2024 | Updated September 2026, 1 week ago
There’s only one alliterative phrase i like more than 'the sheekey science show', and that’s 'anti-aging antibodies'. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper - immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month - Inhibition of IL-11 signalling extends mammalian healthspan.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Antibodies - 00:45
Inhibiting protein damage - 02:15
Inhibiting IL-11 - 05:20
REFERENCES
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation - doi.org/10.15252/emmm.202318526
Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). doi.org/10.1038/s41586-024-07701-9
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
There’s only one alliterative phrase i like more than 'the sheekey science show', and that’s 'anti-aging antibodies'. now, as it happens, one thing i spent a lot of time working on this year is antibodies. Antibody, make me feel this way. now while i cannot tell you yet what i was/am doing, i can tell you about two recent science stories that exploit antibodies to extend mouse lifespan. Firstly, i will bring your attention to this paper - immunotherapy targeting isoDGR-protein damage extends lifespan and then we’ll look at this paper that came out last month - Inhibition of IL-11 signalling extends mammalian healthspan.
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Antibodies - 00:45
Inhibiting protein damage - 02:15
Inhibiting IL-11 - 05:20
REFERENCES
Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation - doi.org/10.15252/emmm.202318526
Widjaja, A.A., Lim, WW., Viswanathan, S. et al. Inhibition of IL-11 signalling extends mammalian healthspan and lifespan. Nature 632, 157–165 (2024). doi.org/10.1038/s41586-024-07701-9
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
