Uploaded July 2020 | Updated September 2026, 1 week ago
The mechanism for the synthesis of Albuterol (Salbutamol) which involves a four-step process. Beginning with methyl salicylate, an acylation is first conducted with bromoacetyl chloride in order to produce the desired bromoketone. This is then reacted with N-benzyl-N-t-butyl amine in order to produce the aminoketone. The ketone and ester present are then reduced to alcohols using lithium aluminum hydride (LiAlH4) to yield the triol. The compound is then deprotected with the removal of the benzyl group by use of a Pd-C catalyst with hydrogen gas. Once complete, albuterol is obtained.
Music: Slow Times Over Here – YouTube Audio Library
The mechanism for the synthesis of Albuterol (Salbutamol) which involves a four-step process. Beginning with methyl salicylate, an acylation is first conducted with bromoacetyl chloride in order to produce the desired bromoketone. This is then reacted with N-benzyl-N-t-butyl amine in order to produce the aminoketone. The ketone and ester present are then reduced to alcohols using lithium aluminum hydride (LiAlH4) to yield the triol. The compound is then deprotected with the removal of the benzyl group by use of a Pd-C catalyst with hydrogen gas. Once complete, albuterol is obtained.
Music: Slow Times Over Here – YouTube Audio Library
