Fries Rearrangement Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded September 2021 | Updated September 2026, 1 week ago

The mechanism for a Fries rearrangement which is used to convert a phenyl ester to an ortho- and para-hydroxy aryl ketone using a Lewis acid catalyst and acid work-up. The mechanism begins with coordination of the ester to the Lewis acid. This is then followed by a rearrangement which can take place through two different pathways. An acid work-up is then used to regenerate the Lewis acid catalyst and yield the two hydroxy aryl ketone products.

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