Shibasaki Cyclization Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded July 2021 | Updated September 2026, 1 week ago

The mechanism for a Shibasaki Cyclization in which a cyclized amide is produced from a ketone starting material. A bromine is necessary in the starting material as well in order to have insertion by the palladium catalyst followed by coordination and subsequent insertion by the CO. A titanium catalyst is then introduced in order to supply the nitrogen necessary for the final amide formation.

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