Fischer Indole Synthesis Mechanism | Organic Chemistry @OrganicMechanismsChannel

Uploaded January 2021 | Updated September 2026, 1 week ago

The mechanism for a Fischer Indole reaction in which an aromatic heterocycle is produced from a phenylhydrazine and aldehyde or ketone under acidic conditions. Various Bronsted acids as well as Lewis acids are often used as the acid catalysts for this reaction.

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