Uploaded November 2025 | Updated September 2026, 1 week ago
Link: open.substack.com/pub/staycuriousmetabolism/p/how-berberine-lowers-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
A fascinating study in Nature Medicine uncovered that berberine lowers LDL and ApoB through a mechanism totally different from statins — by extending the lifespan of the mRNA blueprints your liver uses to build LDL receptors.
This isn’t about blocking cholesterol synthesis.
This doesn’t harm mitochondria or raising blood sugar or slash GLP-1 (like statins).
It’s about boosting LDL receptor production by taking the instructions coding for these receptors and making them last three-times longer!
If you want the mechanisms, limitations, and what this means for LDL, ApoB, and metabolic health, check the link in the description.
#cholesterol #LDL #ApoB #berberine #hearthealth #statins #longevity #HealthScience #NickNorwitz #Metabolism #NatureMedicine #StayCurious
Link: open.substack.com/pub/staycuriousmetabolism/p/how-berberine-lowers-cholesterol?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
A fascinating study in Nature Medicine uncovered that berberine lowers LDL and ApoB through a mechanism totally different from statins — by extending the lifespan of the mRNA blueprints your liver uses to build LDL receptors.
This isn’t about blocking cholesterol synthesis.
This doesn’t harm mitochondria or raising blood sugar or slash GLP-1 (like statins).
It’s about boosting LDL receptor production by taking the instructions coding for these receptors and making them last three-times longer!
If you want the mechanisms, limitations, and what this means for LDL, ApoB, and metabolic health, check the link in the description.
#cholesterol #LDL #ApoB #berberine #hearthealth #statins #longevity #HealthScience #NickNorwitz #Metabolism #NatureMedicine #StayCurious
