Uploaded February 2026 | Updated September 2026, 1 week ago
LINK: staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2
Statins are among the most prescribed drugs in the world—but their metabolic effects deserve closer inspection. In a controlled 4-month human trial, statin therapy was shown to significantly lower GLP-1, a hormone involved in glucose regulation and insulin sensitivity. Separate mechanistic data suggest that even low doses of atorvastatin may impair mitochondrial complex IV activity, raising important questions about cellular energy and metabolic trade-offs. This isn’t an argument against statins—it’s a reminder that every intervention has benefits and costs. This is a quick version—check the deep-dive letter for the nuance and limitations.
#Statins #HeartHealth #GLP1 #Mitochondria #MetabolicHealth #Diabetes #CardioScience #StayCurious
LINK: staycuriousmetabolism.substack.com/p/this-study-should-have-changed-medicineno?r=40ekz2
Statins are among the most prescribed drugs in the world—but their metabolic effects deserve closer inspection. In a controlled 4-month human trial, statin therapy was shown to significantly lower GLP-1, a hormone involved in glucose regulation and insulin sensitivity. Separate mechanistic data suggest that even low doses of atorvastatin may impair mitochondrial complex IV activity, raising important questions about cellular energy and metabolic trade-offs. This isn’t an argument against statins—it’s a reminder that every intervention has benefits and costs. This is a quick version—check the deep-dive letter for the nuance and limitations.
#Statins #HeartHealth #GLP1 #Mitochondria #MetabolicHealth #Diabetes #CardioScience #StayCurious
