Uploaded February 2026 | Updated September 2026, 1 week ago
For all the references and early access to content like this, see the letter: staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2
Try Winnow Labs Probiotic: winnowlabs.com/STAYCURIOUS
Code “StayCurious” for 15% off
Learn more about microplastics and human health below
Interview with CEO, Matthew Dunn PhD: youtu.be/9jSZh6kqfuE
Microplastics & Brain Health: open.substack.com/pub/staycuriousmetabolism/p/this-graph-changed-how-i-think-about?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Microplastics & Heart Health: staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2
Constipation Masterclass: open.substack.com/pub/staycuriousmetabolism/p/the-constipation-masterclass?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Lithium video: youtu.be/Hcz0Eyp1LE4
Description:
Modern life is hostile to the human microbiome. Processed food, antibiotics, artificial sweeteners, stress, and disrupted circadian rhythms have pushed our gut ecosystems far from what our biology evolved to handle. In this video, I walk through a self-experimental framework for resetting the microbiome. We’ll cover a 4-phase microbiome reset: elimination, early repopulation, advanced repopulation, and long-term maintenance. This is not medical advice. It’s a structured way to explore your N=1 safely.
Chapters
0:00 – Can You Truly Reset Your Microbiome?
1:36 – The 4-Phase Microbiome Reset Framework
1:58 – Phase 1: Elimination (Starving Problematic Gut Bacteria)
5:40 – Phase 2: Careful Repopulation (Rebuilding the Microbiome)
11:13 – Phase 3: Expansion & Food Challenges
12:18 – Phase 4: Long-Term Maintenance & Resilience
#gutmicrobiome #microbiomereset #gutbrainaxis #digestivewellness #leakygut #dysbiosis #IBDawareness #inflammationhealth #metabolicflexibility #insulinsensitivity #bloodsugarcontrol #hormonehealth #circadianrhythm #stressandhealth #vagusnerve #fermentedfoods #probioticscience #prebiotics #eliminationdiet #carnivorediet #microbiome #guthealth #digestivehealth #metabolichealth #inflammation #IBD #insulinresistance #nutritionscience #staycurious
For all the references and early access to content like this, see the letter: staycuriousmetabolism.substack.com/p/how-im-rebuilding-my-microbiomeafter?r=40ekz2
Try Winnow Labs Probiotic: winnowlabs.com/STAYCURIOUS
Code “StayCurious” for 15% off
Learn more about microplastics and human health below
Interview with CEO, Matthew Dunn PhD: youtu.be/9jSZh6kqfuE
Microplastics & Brain Health: open.substack.com/pub/staycuriousmetabolism/p/this-graph-changed-how-i-think-about?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Microplastics & Heart Health: staycuriousmetabolism.substack.com/p/microplastics-in-my-heart-its-worse?r=40ekz2
Constipation Masterclass: open.substack.com/pub/staycuriousmetabolism/p/the-constipation-masterclass?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Lithium video: youtu.be/Hcz0Eyp1LE4
Description:
Modern life is hostile to the human microbiome. Processed food, antibiotics, artificial sweeteners, stress, and disrupted circadian rhythms have pushed our gut ecosystems far from what our biology evolved to handle. In this video, I walk through a self-experimental framework for resetting the microbiome. We’ll cover a 4-phase microbiome reset: elimination, early repopulation, advanced repopulation, and long-term maintenance. This is not medical advice. It’s a structured way to explore your N=1 safely.
Chapters
0:00 – Can You Truly Reset Your Microbiome?
1:36 – The 4-Phase Microbiome Reset Framework
1:58 – Phase 1: Elimination (Starving Problematic Gut Bacteria)
5:40 – Phase 2: Careful Repopulation (Rebuilding the Microbiome)
11:13 – Phase 3: Expansion & Food Challenges
12:18 – Phase 4: Long-Term Maintenance & Resilience
#gutmicrobiome #microbiomereset #gutbrainaxis #digestivewellness #leakygut #dysbiosis #IBDawareness #inflammationhealth #metabolicflexibility #insulinsensitivity #bloodsugarcontrol #hormonehealth #circadianrhythm #stressandhealth #vagusnerve #fermentedfoods #probioticscience #prebiotics #eliminationdiet #carnivorediet #microbiome #guthealth #digestivehealth #metabolichealth #inflammation #IBD #insulinresistance #nutritionscience #staycurious







![Can Fiber Damage Your Liver?
Link: https://open.substack.com/pub/staycuriousmetabolism/p/fiber-is-good-for-you-is-lazy-s[…]kz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
We’re told fiber is always good—but that’s not the full story. A landmark randomized controlled trial from Stanford tested different fiber types and found that one common fiber, when taken at high doses, significantly increased ALT, a marker of liver injury, in a subset of people. The effect was large enough that researchers stopped the study early for safety concerns.
At lower doses, the same fiber may improve insulin sensitivity and reduce fatty liver, highlighting a key takeaway in nutrition science: dose and individual response matter. This isn’t about fear—it’s about context over dogma.
#Fiber #LiverHealth #NutritionScience #MetabolicHealth #InsulinResistance #FattyLiver #Stanford #RCT #HealthScience #PrecisionNutrition #MedicalEducation #StayCurious Can Fiber Damage Your Liver?](https://i.ytimg.com/vi/HLfFCjEETCY/mqdefault.jpg)


