Uploaded April 2026 | Updated September 2026, 2 weeks ago

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Dr. Lauren Colenso-Semple and Dr. Andrew Huberman discuss the physiological effects of training in a fasted versus fed state, highlighting that muscle and fat adaptations are similar across genders and explaining why total daily protein intake is more critical for results than adhering to a narrow post-workout anabolic window.

Dr. Lauren Colenso-Semple, PhD, is an expert in the science of strength and muscle building and nutrition. Dr. Andrew Huberman is a tenured professor of neurobiology and ophthalmology at Stanford University School of Medicine and host of the Huberman Lab podcast.

Watch the full episode: youtu.be/_Q4XT82yd-Q?si=y1eHD-R3fpnYqpZq
Show notes: go.hubermanlab.com/97OwnrA

*Timestamps*
00:00 Fasted Versus Fed Training
03:18 Caffeine & Exercise Performance
04:28 Pre-Workout Nutrition Facts
06:09 Anabolic Window Myth
08:07 Optimizing Daily Protein Intake

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Disclaimer & Disclosures: hubermanlab.com/disclaimer