![Neuroscientist: #1 Way To Lose Weight & Double Autophagy [EAT THIS] @ThePrimal.Podcast](https://i.ytimg.com/vi/hzU7mLn6A1A/maxresdefault.jpg)
Uploaded April 2026 | Updated September 2026, 1 day ago
The science-backed protocol to double autophagy and lose weight using sardine fasting, with Dr. Dom D’Agostino. Try ARMRA Colostrum for yourself, go to armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order.
Is there a single "metabolic switch" that can accelerate weight loss while repairing your cells? In this episode, world-renowned metabolic researcher Dr. Dom D’Agostino (PhD) joins us to explain the science of autophagy, ketosis, and the gut microbiome. Referencing decades of laboratory research and clinical observation, Dr. D’Agostino explains why the traditional "calories in, calories out" model fails to account for cellular signaling and nutrient density. From the specific biochemical benefits of "sardine fasting" to the role of ketones in preserving gut barrier integrity, this conversation provides the medical clarity needed to optimize your biology. Whether you are looking to reverse metabolic dysfunction or seeking the latest data on nutritional ketosis, this episode bridges the gap between science and practical human experience.
In This Episode, We Reveal:
* The Autophagy Switch: A scientific breakdown of how to double cellular "cleanup" and the specific dietary triggers that initiate protein recycling.
* The Sardine Fasting Protocol: Why this specific high-protein, high-omega-3 approach is a clinical powerhouse for metabolic health and rapid ketosis.
* Ketosis & Disease Prevention: Moving beyond the scale to understand how ketones function as signaling molecules for longevity and neuroprotection.
* Gut Barrier Integrity: The relationship between the microbiome and metabolic health, and why maintaining the gut lining is the first line of defense against systemic inflammation.
* Translating Research to Reality: How to apply cutting-edge metabolic data to daily life for sustainable weight loss and disease prevention.
Our Sponsor:
ARMRA: Try ARMRA Colostrum for yourself, go to armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
MeatStock: Get $100 off every ticket, that’s a 25% discount, exclusively at theprimal.com/meatstock-2026-tickets
Scientific Resources & Dr. D’Agostino’s Work:
* Journal Article: Ketogenic Diet and Metabolic Health (Springer): link.springer.com/article/10.1186/s12916-024-03775-4
* Clinical Research: Metabolic Switching and Health (PubMed): pubmed.ncbi.nlm.nih.gov/37057184
* Historical Context: Nutritional Ketosis in Medicine (PubMed): pubmed.ncbi.nlm.nih.gov/41562187
* Dr. D'Agostino’s Website & Research: ketonutrition.org
Timestamps:
00:00 – Intro
02:11 – The One Biomarker That Rules Them All
04:27 – What Is Sardine Fasting?
12:05 – His Body Changed In 3 Days
15:39 – Does Sardine Fasting Target Visceral Fat?
16:33 – His Insulin Was Flagged As "Too Low"
18:25 – The Cholesterol Debate On Keto
21:42 – Bone Health On A Ketogenic Diet
25:13 – Which Sardines To Buy And How Often
28:14 – The 3-Day Monthly Reset
31:45 – What Ketosis Does To Your Gut
34:34 – Can Ketones Protect Your Brain?
37:46 – The Powerlifter Who Was Told He'd Die
44:44 – Ketones And The Longevity Pathways
50:10 – The Blood Marker More Important Than LDL
55:36 – Does MCT Oil Actually Boost Ketones?
59:37 – Five Foods A Neuroscientist Eats Daily
01:09:43 – The One Keto Food Quietly Killing Your Results
Primal Resources:
* Primal Tallow Balms & Soaps: shop.theprimal.com
* GoCarnivore App: gocarnivore.com
Connect With Us:
* Website: theprimal.com
* Instagram: @theprimal.podcast
* Twitter/X: @ThePrimal_Pod
About Rina Ahluwalia & The Primal Podcast: Rina Ahluwalia is a leading researcher in root-cause healing and the founder of GoCarnivore.com. She facilitates high-level clinical discussions with world-renowned MDs and researchers to deconstruct the pathophysiology of modern disease and promote the science of the Proper Human Diet.
Medical Disclaimer Note: The content provided in this video and description is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this channel.
The science-backed protocol to double autophagy and lose weight using sardine fasting, with Dr. Dom D’Agostino. Try ARMRA Colostrum for yourself, go to armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order.
Is there a single "metabolic switch" that can accelerate weight loss while repairing your cells? In this episode, world-renowned metabolic researcher Dr. Dom D’Agostino (PhD) joins us to explain the science of autophagy, ketosis, and the gut microbiome. Referencing decades of laboratory research and clinical observation, Dr. D’Agostino explains why the traditional "calories in, calories out" model fails to account for cellular signaling and nutrient density. From the specific biochemical benefits of "sardine fasting" to the role of ketones in preserving gut barrier integrity, this conversation provides the medical clarity needed to optimize your biology. Whether you are looking to reverse metabolic dysfunction or seeking the latest data on nutritional ketosis, this episode bridges the gap between science and practical human experience.
In This Episode, We Reveal:
* The Autophagy Switch: A scientific breakdown of how to double cellular "cleanup" and the specific dietary triggers that initiate protein recycling.
* The Sardine Fasting Protocol: Why this specific high-protein, high-omega-3 approach is a clinical powerhouse for metabolic health and rapid ketosis.
* Ketosis & Disease Prevention: Moving beyond the scale to understand how ketones function as signaling molecules for longevity and neuroprotection.
* Gut Barrier Integrity: The relationship between the microbiome and metabolic health, and why maintaining the gut lining is the first line of defense against systemic inflammation.
* Translating Research to Reality: How to apply cutting-edge metabolic data to daily life for sustainable weight loss and disease prevention.
Our Sponsor:
ARMRA: Try ARMRA Colostrum for yourself, go to armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
MeatStock: Get $100 off every ticket, that’s a 25% discount, exclusively at theprimal.com/meatstock-2026-tickets
Scientific Resources & Dr. D’Agostino’s Work:
* Journal Article: Ketogenic Diet and Metabolic Health (Springer): link.springer.com/article/10.1186/s12916-024-03775-4
* Clinical Research: Metabolic Switching and Health (PubMed): pubmed.ncbi.nlm.nih.gov/37057184
* Historical Context: Nutritional Ketosis in Medicine (PubMed): pubmed.ncbi.nlm.nih.gov/41562187
* Dr. D'Agostino’s Website & Research: ketonutrition.org
Timestamps:
00:00 – Intro
02:11 – The One Biomarker That Rules Them All
04:27 – What Is Sardine Fasting?
12:05 – His Body Changed In 3 Days
15:39 – Does Sardine Fasting Target Visceral Fat?
16:33 – His Insulin Was Flagged As "Too Low"
18:25 – The Cholesterol Debate On Keto
21:42 – Bone Health On A Ketogenic Diet
25:13 – Which Sardines To Buy And How Often
28:14 – The 3-Day Monthly Reset
31:45 – What Ketosis Does To Your Gut
34:34 – Can Ketones Protect Your Brain?
37:46 – The Powerlifter Who Was Told He'd Die
44:44 – Ketones And The Longevity Pathways
50:10 – The Blood Marker More Important Than LDL
55:36 – Does MCT Oil Actually Boost Ketones?
59:37 – Five Foods A Neuroscientist Eats Daily
01:09:43 – The One Keto Food Quietly Killing Your Results
Primal Resources:
* Primal Tallow Balms & Soaps: shop.theprimal.com
* GoCarnivore App: gocarnivore.com
Connect With Us:
* Website: theprimal.com
* Instagram: @theprimal.podcast
* Twitter/X: @ThePrimal_Pod
About Rina Ahluwalia & The Primal Podcast: Rina Ahluwalia is a leading researcher in root-cause healing and the founder of GoCarnivore.com. She facilitates high-level clinical discussions with world-renowned MDs and researchers to deconstruct the pathophysiology of modern disease and promote the science of the Proper Human Diet.
Medical Disclaimer Note: The content provided in this video and description is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this channel.
![Neuroscientist: #1 Way To Lose Weight & Double Autophagy [EAT THIS]](https://i.ytimg.com/vi/hzU7mLn6A1A/mqdefault.jpg "Neuroscientist: #1 Way To Lose Weight & Double Autophagy [EAT THIS]
The science-backed protocol to double autophagy and lose weight using sardine fasting, with Dr. Dom D’Agostino. Try ARMRA Colostrum for yourself, go to https://armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order.
Is there a single metabolic switch that can accelerate weight loss while repairing your cells? In this episode, world-renowned metabolic researcher Dr. Dom D’Agostino (PhD) joins us to explain the science of autophagy, ketosis, and the gut microbiome. Referencing decades of laboratory research and clinical observation, Dr. D’Agostino explains why the traditional calories in, calories out model fails to account for cellular signaling and nutrient density. From the specific biochemical benefits of sardine fasting to the role of ketones in preserving gut barrier integrity, this conversation provides the medical clarity needed to optimize your biology. Whether you are looking to reverse metabolic dysfunction or seeking the latest data on nutritional ketosis, this episode bridges the gap between science and practical human experience.
In This Episode, We Reveal:
* The Autophagy Switch: A scientific breakdown of how to double cellular cleanup and the specific dietary triggers that initiate protein recycling.
* The Sardine Fasting Protocol: Why this specific high-protein, high-omega-3 approach is a clinical powerhouse for metabolic health and rapid ketosis.
* Ketosis & Disease Prevention: Moving beyond the scale to understand how ketones function as signaling molecules for longevity and neuroprotection.
* Gut Barrier Integrity: The relationship between the microbiome and metabolic health, and why maintaining the gut lining is the first line of defense against systemic inflammation.
* Translating Research to Reality: How to apply cutting-edge metabolic data to daily life for sustainable weight loss and disease prevention.
Our Sponsor:
ARMRA: Try ARMRA Colostrum for yourself, go to armra.com/theprimalpodcast or enter code THEPRIMALPODCAST to get 15% off your first order. These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
MeatStock: Get $100 off every ticket, that’s a 25% discount, exclusively at https://www.theprimal.com/meatstock-2026-tickets
Scientific Resources & Dr. D’Agostino’s Work:
* Journal Article: Ketogenic Diet and Metabolic Health (Springer): https://link.springer.com/article/10.1186/s12916-024-03775-4
* Clinical Research: Metabolic Switching and Health (PubMed): https://pubmed.ncbi.nlm.nih.gov/37057184/
* Historical Context: Nutritional Ketosis in Medicine (PubMed): https://pubmed.ncbi.nlm.nih.gov/41562187/
* Dr. DAgostino’s Website & Research: https://ketonutrition.org/
Timestamps:
00:00 – Intro
02:11 – The One Biomarker That Rules Them All
04:27 – What Is Sardine Fasting?
12:05 – His Body Changed In 3 Days
15:39 – Does Sardine Fasting Target Visceral Fat?
16:33 – His Insulin Was Flagged As Too Low
18:25 – The Cholesterol Debate On Keto
21:42 – Bone Health On A Ketogenic Diet
25:13 – Which Sardines To Buy And How Often
28:14 – The 3-Day Monthly Reset
31:45 – What Ketosis Does To Your Gut
34:34 – Can Ketones Protect Your Brain?
37:46 – The Powerlifter Who Was Told Hed Die
44:44 – Ketones And The Longevity Pathways
50:10 – The Blood Marker More Important Than LDL
55:36 – Does MCT Oil Actually Boost Ketones?
59:37 – Five Foods A Neuroscientist Eats Daily
01:09:43 – The One Keto Food Quietly Killing Your Results
Primal Resources:
* Primal Tallow Balms & Soaps: https://shop.theprimal.com/
* GoCarnivore App: https://www.gocarnivore.com/
Connect With Us:
* Website: https://www.theprimal.com/
* Instagram: @theprimal.podcast
* Twitter/X: @ThePrimal_Pod
About Rina Ahluwalia & The Primal Podcast: Rina Ahluwalia is a leading researcher in root-cause healing and the founder of GoCarnivore.com. She facilitates high-level clinical discussions with world-renowned MDs and researchers to deconstruct the pathophysiology of modern disease and promote the science of the Proper Human Diet.
Medical Disclaimer Note: The content provided in this video and description is for educational and informational purposes only. It is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have heard on this channel.")
