Uploaded July 2024 | Updated September 2026, 1 hour ago
Hyperplasia Hypertrophy
Finally moving to something new, I want to discuss two related topics that tend to come up frequently enough that they are worth addressing.
Those are the issues of skeletal muscle hyperplasia, the actual production of new muscle fibers, along with the issue of the conversion of one fiber type into another.
The first topic is back in the conversation due to a recent study that just came out and I decided to cover the second one since my videos are always too short (ha ha) and because my recommendation regarding the topic is identical.
store.bodyrecomposition.com
bodyrecomposition.com
IG: @mcdonaldlyle
My awesome Facebook group: facebook.com/groups/810890695609053
Questions for me to ignore: questions@bodyrecomposition.com
I also do Zoom consultations now if you want me to tell you how to live your life:
store.bodyrecomposition.com/shop/consulting-lyle-mcdonald
#hypertrophy #hyperplasia #fibertype #andygalpin
*********
Some of the cited references. I've included links to free full text when possible (for most of the older papers it's not)
The most recent paper suggesting hyperplasia occurs.
Maeo S et al. Long-term resistance trained human muscles have more fibers, more myofibrils and tighter myofilament packing than untrained. Med Sci Sports Exerc (2024) Jun 19. doi: 10.1249/MSS.0000000000003495. Online ahead of print.
https://shorturl.at/dkr51
One of the earliest studies suggesting muscle hyperplasia. IN CATS!
Gonyea W et al. Skeletal muscle fiber splitting induced by weight-lifting exercise in cats. Acta Physiol Scand (1977) 99:105-109.
pubmed.ncbi.nlm.nih.gov/139079
MacDougall's work on elite bodybuilders suggesting a greater number of muscle fibers.
MacDougall JD et al. Muscle fiber number in biceps brachii in bodybuilders and control subjects. J Apple Physiol (1984) 57: 1399-1403.
pubmed.ncbi.nlm.nih.gov/6520032
The paper showing hyperplasia in anabolic using powerlifters
Kadi F et al. Effects of anabolic steroids on the muscle cells of strength-trained athletes. Med Sci Sports Exerc (1999) 31: 1528-1534
pubmed.ncbi.nlm.nih.gov/10589853
The paper showing incredible muscle hypertrophy along with hyperplasia in quail
Antonio J and WJ Gonyea. Progressive stretch overload of skeletal muscle results in hypertrophy before hyperplasia J Appl Physiol (1985) (1993) 75: 1263-1271
pubmed.ncbi.nlm.nih.gov/8226539
Dr. Galpin's study of elite weightlifters and fiber type
Serrano N et al. Extraordinary fast-twitch fiber abundance in elite weightlifters. PLoS One (2019) 14: e0207975
ncbi.nlm.nih.gov/pmc/articles/PMC6436686
The case study of two twins after 30 yeras of either endurance or no training
Bathgate KE et al. Muscle Health and performance in monozygotic twins with 30 year of discordant exercise habits. Eur J Apple Physiol (2018) 118: 2097-2110
pubmed.ncbi.nlm.nih.gov/30006671
A good review including the history of muscle fiber typing for the nerds
Blemker SS et al. Fiber-type traps: revisiting common misconceptions about skeletal muscle fiber types with application to motor control, biomechanics, physiology and biology. J Appl Physiol(1985) (2024) 136:109-121.
https://shorturl.at/VOq0Z
youtu.be/gpn90jmUFnM
Hyperplasia Hypertrophy
Finally moving to something new, I want to discuss two related topics that tend to come up frequently enough that they are worth addressing.
Those are the issues of skeletal muscle hyperplasia, the actual production of new muscle fibers, along with the issue of the conversion of one fiber type into another.
The first topic is back in the conversation due to a recent study that just came out and I decided to cover the second one since my videos are always too short (ha ha) and because my recommendation regarding the topic is identical.
store.bodyrecomposition.com
bodyrecomposition.com
IG: @mcdonaldlyle
My awesome Facebook group: facebook.com/groups/810890695609053
Questions for me to ignore: questions@bodyrecomposition.com
I also do Zoom consultations now if you want me to tell you how to live your life:
store.bodyrecomposition.com/shop/consulting-lyle-mcdonald
#hypertrophy #hyperplasia #fibertype #andygalpin
*********
Some of the cited references. I've included links to free full text when possible (for most of the older papers it's not)
The most recent paper suggesting hyperplasia occurs.
Maeo S et al. Long-term resistance trained human muscles have more fibers, more myofibrils and tighter myofilament packing than untrained. Med Sci Sports Exerc (2024) Jun 19. doi: 10.1249/MSS.0000000000003495. Online ahead of print.
https://shorturl.at/dkr51
One of the earliest studies suggesting muscle hyperplasia. IN CATS!
Gonyea W et al. Skeletal muscle fiber splitting induced by weight-lifting exercise in cats. Acta Physiol Scand (1977) 99:105-109.
pubmed.ncbi.nlm.nih.gov/139079
MacDougall's work on elite bodybuilders suggesting a greater number of muscle fibers.
MacDougall JD et al. Muscle fiber number in biceps brachii in bodybuilders and control subjects. J Apple Physiol (1984) 57: 1399-1403.
pubmed.ncbi.nlm.nih.gov/6520032
The paper showing hyperplasia in anabolic using powerlifters
Kadi F et al. Effects of anabolic steroids on the muscle cells of strength-trained athletes. Med Sci Sports Exerc (1999) 31: 1528-1534
pubmed.ncbi.nlm.nih.gov/10589853
The paper showing incredible muscle hypertrophy along with hyperplasia in quail
Antonio J and WJ Gonyea. Progressive stretch overload of skeletal muscle results in hypertrophy before hyperplasia J Appl Physiol (1985) (1993) 75: 1263-1271
pubmed.ncbi.nlm.nih.gov/8226539
Dr. Galpin's study of elite weightlifters and fiber type
Serrano N et al. Extraordinary fast-twitch fiber abundance in elite weightlifters. PLoS One (2019) 14: e0207975
ncbi.nlm.nih.gov/pmc/articles/PMC6436686
The case study of two twins after 30 yeras of either endurance or no training
Bathgate KE et al. Muscle Health and performance in monozygotic twins with 30 year of discordant exercise habits. Eur J Apple Physiol (2018) 118: 2097-2110
pubmed.ncbi.nlm.nih.gov/30006671
A good review including the history of muscle fiber typing for the nerds
Blemker SS et al. Fiber-type traps: revisiting common misconceptions about skeletal muscle fiber types with application to motor control, biomechanics, physiology and biology. J Appl Physiol(1985) (2024) 136:109-121.
https://shorturl.at/VOq0Z
youtu.be/gpn90jmUFnM
