Uploaded August 2026 | Updated September 2026, 3 weeks ago
Book a free consultation call with Robert Sikes to break through your keto or low-carb plateau: ketobodybuilding.com/call
Your heart was built to burn fat, not sugar, and losing that ability may drive heart disease. In episode 909 of the Savage Perspective Podcast, host Robert Sikes and Dr. Anthony Jay break down how insulin resistance can leave the heart low on fuel as LDL cholesterol and artery plaque rise. They cover HOMA-IR, statins, coronary calcium scans, CCTA, familial hypercholesterolemia, Lp(a), seed oils, inflammation, and microplastics. Dr. Jay shares why low LDL may not fix the root cause, when statins can help, and how fasting, a low-carb diet, and metabolic flexibility may support heart health. Watch to learn which tests matter and what common heart advice may miss.
Buy Anthony's new book: amzn.to/4xycguP
Follow on IG: instagram.com/anthonygjay
Get Keto Brick: ketobrick.com
Subscribe to the podcast: open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQ
Chapters
0:00 - Why Dr. Anthony Jay Took On Heart Disease
1:04 - Does Insulin Resistance Cause Heart Disease?
5:21 - How Do You Test for Insulin Resistance?
8:43 - What Is the “Starving Heart” Theory?
10:48 - Why Can a High-Fat Diet Raise LDL Cholesterol?
13:02 - Do Statins Increase Coronary Calcium?
16:21 - How Accurate Are CCTA and AI Plaque Scans?
24:24 - When Is a Coronary Angiogram Actually Worth It?
27:09 - When Do Statins Actually Help?
29:33 - What Counts as True Familial Hypercholesterolemia?
34:18 - Why Did Oreo Cookies Lower LDL Cholesterol?
36:30 - Can Statins and Repatha Raise Diabetes Risk?
38:17 - Can Fat Burning Help Reverse Artery Plaque?
42:50 - Can Fasting Reverse Insulin Resistance and Plaque?
44:34 - Which Heart Disease Risks Do Standard Tests Miss?
46:00 - What Is Lp(a), and Why Does It Rise?
48:22 - Is Lp(a) Really Genetic and Unchangeable?
53:01 - Are Seed Oils Bad for Your Arteries?
55:42 - Can Blood Tests Really Measure Inflammation?
1:00:47 - How Long Do Seed Oils Stay in Your Body?
1:03:31 - Why Do Experts Disagree About Seed Oils?
1:06:07 - Should Healthy People Worry About Restaurant Seed Oils?
1:08:40 - Is Alzheimer’s Really Type 3 Diabetes?
1:10:43 - How Do Plastics and Polyester Disrupt Hormones?
1:12:14 - Are Microplastics Hiding Inside Artery Plaque?
1:17:37 - Dr. Anthony Jay’s New Book, Sugar Beat
Book a free consultation call with Robert Sikes to break through your keto or low-carb plateau: ketobodybuilding.com/call
Your heart was built to burn fat, not sugar, and losing that ability may drive heart disease. In episode 909 of the Savage Perspective Podcast, host Robert Sikes and Dr. Anthony Jay break down how insulin resistance can leave the heart low on fuel as LDL cholesterol and artery plaque rise. They cover HOMA-IR, statins, coronary calcium scans, CCTA, familial hypercholesterolemia, Lp(a), seed oils, inflammation, and microplastics. Dr. Jay shares why low LDL may not fix the root cause, when statins can help, and how fasting, a low-carb diet, and metabolic flexibility may support heart health. Watch to learn which tests matter and what common heart advice may miss.
Buy Anthony's new book: amzn.to/4xycguP
Follow on IG: instagram.com/anthonygjay
Get Keto Brick: ketobrick.com
Subscribe to the podcast: open.spotify.com/show/42cjJssghqD01bdWBxRYEg?si=1XYKmPXmR4eKw2O9gGCEuQ
Chapters
0:00 - Why Dr. Anthony Jay Took On Heart Disease
1:04 - Does Insulin Resistance Cause Heart Disease?
5:21 - How Do You Test for Insulin Resistance?
8:43 - What Is the “Starving Heart” Theory?
10:48 - Why Can a High-Fat Diet Raise LDL Cholesterol?
13:02 - Do Statins Increase Coronary Calcium?
16:21 - How Accurate Are CCTA and AI Plaque Scans?
24:24 - When Is a Coronary Angiogram Actually Worth It?
27:09 - When Do Statins Actually Help?
29:33 - What Counts as True Familial Hypercholesterolemia?
34:18 - Why Did Oreo Cookies Lower LDL Cholesterol?
36:30 - Can Statins and Repatha Raise Diabetes Risk?
38:17 - Can Fat Burning Help Reverse Artery Plaque?
42:50 - Can Fasting Reverse Insulin Resistance and Plaque?
44:34 - Which Heart Disease Risks Do Standard Tests Miss?
46:00 - What Is Lp(a), and Why Does It Rise?
48:22 - Is Lp(a) Really Genetic and Unchangeable?
53:01 - Are Seed Oils Bad for Your Arteries?
55:42 - Can Blood Tests Really Measure Inflammation?
1:00:47 - How Long Do Seed Oils Stay in Your Body?
1:03:31 - Why Do Experts Disagree About Seed Oils?
1:06:07 - Should Healthy People Worry About Restaurant Seed Oils?
1:08:40 - Is Alzheimer’s Really Type 3 Diabetes?
1:10:43 - How Do Plastics and Polyester Disrupt Hormones?
1:12:14 - Are Microplastics Hiding Inside Artery Plaque?
1:17:37 - Dr. Anthony Jay’s New Book, Sugar Beat
