Uploaded December 2025 | Updated September 2026, 2 weeks ago
Dom D’Agostino Part 1 Interview: youtu.be/ksV9f4jSbLQ
Creatine Letter: staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2
Sardine Diet Letter: staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2
Sardine Diet Video: youtu.be/_Th54GWd8WY
Lived to 117 Letter: staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2
Lived to 117 Video: youtu.be/U7UY8ZPKNlM
Stress Makes Sugar Letter: staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress Makes Sugar Video: youtu.be/7ekVEYlKFfE
This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits.
We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.
We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker.
And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.
Chapters
0:00 – Welcome Back Professor D’Agostino
1:34 – Does Melatonin Suppress Your Hormones?
6:27 – Real Benefits of Melatonin
8:00 – Creatine for Brain Health
10:24 – How to Reduce GI Upset from Creatine
14:04 – How Did This Woman Live to 117?
30:00 – Sardine Fasting: The Most Elite Form of Fasting
#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife
Dom D’Agostino Part 1 Interview: youtu.be/ksV9f4jSbLQ
Creatine Letter: staycuriousmetabolism.substack.com/p/creatine-explained-how-one-molecule?r=40ekz2
Sardine Diet Letter: staycuriousmetabolism.substack.com/p/sardine-fasting-the-ultimate-health?r=40ekz2
Sardine Diet Video: youtu.be/_Th54GWd8WY
Lived to 117 Letter: staycuriousmetabolism.substack.com/p/the-oldest-woman-117-had-high-cholesterol?r=40ekz2
Lived to 117 Video: youtu.be/U7UY8ZPKNlM
Stress Makes Sugar Letter: staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress Makes Sugar Video: youtu.be/7ekVEYlKFfE
This interview with Professor Dom D’Agostino is one of the most information-dense conversations I’ve had on the channel. We dive into the real science behind melatonin — why it doesn’t suppress your hormones and why its neuroprotective effects might matter more than its sleep benefits.
We explore creatine far beyond muscle performance, including its impact on brain energy and cognitive resilience, and how to take it without the GI issues many people experience.
We also break down the surprising biology of a verified 117-year-old woman, what her data reveals about longevity, and why factors like mindset, mitochondria, and microbiome may matter more than any single biomarker.
And finally, we tackle sardine fasting — why it may be the most elite, nutrient-dense, muscle-sparing fasting protocol available. If you want cutting-edge science translated into practical strategies for metabolic health, brain health, and longevity, this is the episode to watch.
Chapters
0:00 – Welcome Back Professor D’Agostino
1:34 – Does Melatonin Suppress Your Hormones?
6:27 – Real Benefits of Melatonin
8:00 – Creatine for Brain Health
10:24 – How to Reduce GI Upset from Creatine
14:04 – How Did This Woman Live to 117?
30:00 – Sardine Fasting: The Most Elite Form of Fasting
#melatonin #creatine #sardines #sardinediet #fasting #longevity #brainhealth #metabolichealth #neuroprotection #omega3 #NickNorwitz #DomDAgostino #StayCurious #nutritionresearch #healthscience #biohacking #antiaging #ketodiet #ketosis #healthoptimization #supplements #exercisephysiology #functionalnutrition #lowcarb #cholesterol #labresults #epigenetics #mitochondria #inflammation #mentalclarity #superfoods #metabolismboost #wellnessjourney #lifespan #healthylonglife
