Uploaded April 2026 | Updated September 2026, 2 weeks ago
For more nuances and all the references, see the associated StayCurious Metabolism Newsletter: staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2
Cholesterol Mini-Masterclass Letter: staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2
Lithium Video: youtu.be/Hcz0Eyp1LE4
LPC-DHA (Omega-3) Video: youtu.be/B-kEn0FukXM
And to try the Accentrate Omega Max supplement containing LPC-DHA, click HERE: fenixhealthscience.com/staycurious
Use code StayCurious for 20% off.
NAD Letter: staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2
Description
Ezetimibe is usually thought of as a cholesterol-lowering drug. But a new study suggests it may be doing something completely unexpected — in the brain. In this video, I break down fascinating new mechanistic, cellular, animal, and human data suggesting ezetimibe may interrupt a key protein interaction implicated in Alzheimer’s disease and reduce amyloid and tau accumulation, boost autophagy, and associate with dramatically lower rates of dementia.
I also walk through the limitations, safety considerations, my own personal risk–benefit thinking (as someone with ApoE4/4), and what I’m currently doing for brain health. As always, this is not medical advice — it’s an exploration of emerging data so you can make more informed, individualized decisions.
Chapters
0:00 – A Cholesterol Drug… for the Brain?
1:45 – Roadmap to This Video: Background, New Study, Personal Plan, and Brain Health Tips
2:28 – Chapter 1: Background on Ezetimibe and Alzheimer’s Disease
5:30 – Chapter 2: New Study on Ezetimibe and Alzheimer’s Disease
9:40 – Caveats, Limitations, and Clarifications
12:56 – Chapter 3: What I’m Personally Doing Next
14:47 – Chapter 4: High-Yield Rapid Fire Tips for Brain Health
14:51 – Lithium For Brain Health
15:01 – LPC-DHA For Brain Health
15:33 – NAD For Brain Health: NR and NMN
15:53 – Closing Message of Hope for Cognitive Longevity
#Ezetimibe #Alzheimers #Dementia #BrainHealth #Neurodegeneration #Cholesterol #ApoE4 #ApoE4 #CognitiveHealth #Longevity #Neuroscience #MedicalResearch #DrugRepurposing #Autophagy #Amyloid #Tau #ProteinAggregation #Hexokinase #1433Protein #MetabolicHealth #PreventAlzheimers #CognitiveLongevity #Biohacking #HealthScience #StayCurious #NPC1L1 #LDL #Cardiology #Neurology #AgingResearch #AlzheimersPrevention #BrainOptimization #Pharmacology #EvidenceBased #ClinicalScience #TranslationalMedicine #WormModel #CellBiology #MechanisticMedicine #PrecisionHealth #RCT #MedicalEducation #BrainAging #Supplements #LithiumOrotate #Omega3 #LPCDHA #NAD #NMN #NicotinamideRiboside #CETP
For more nuances and all the references, see the associated StayCurious Metabolism Newsletter: staycuriousmetabolism.substack.com/p/this-study-completely-changed-how?r=40ekz2
Cholesterol Mini-Masterclass Letter: staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2
Lithium Video: youtu.be/Hcz0Eyp1LE4
LPC-DHA (Omega-3) Video: youtu.be/B-kEn0FukXM
And to try the Accentrate Omega Max supplement containing LPC-DHA, click HERE: fenixhealthscience.com/staycurious
Use code StayCurious for 20% off.
NAD Letter: staycuriousmetabolism.substack.com/p/never-get-alzheimers-disease-the?r=40ekz2
Description
Ezetimibe is usually thought of as a cholesterol-lowering drug. But a new study suggests it may be doing something completely unexpected — in the brain. In this video, I break down fascinating new mechanistic, cellular, animal, and human data suggesting ezetimibe may interrupt a key protein interaction implicated in Alzheimer’s disease and reduce amyloid and tau accumulation, boost autophagy, and associate with dramatically lower rates of dementia.
I also walk through the limitations, safety considerations, my own personal risk–benefit thinking (as someone with ApoE4/4), and what I’m currently doing for brain health. As always, this is not medical advice — it’s an exploration of emerging data so you can make more informed, individualized decisions.
Chapters
0:00 – A Cholesterol Drug… for the Brain?
1:45 – Roadmap to This Video: Background, New Study, Personal Plan, and Brain Health Tips
2:28 – Chapter 1: Background on Ezetimibe and Alzheimer’s Disease
5:30 – Chapter 2: New Study on Ezetimibe and Alzheimer’s Disease
9:40 – Caveats, Limitations, and Clarifications
12:56 – Chapter 3: What I’m Personally Doing Next
14:47 – Chapter 4: High-Yield Rapid Fire Tips for Brain Health
14:51 – Lithium For Brain Health
15:01 – LPC-DHA For Brain Health
15:33 – NAD For Brain Health: NR and NMN
15:53 – Closing Message of Hope for Cognitive Longevity
#Ezetimibe #Alzheimers #Dementia #BrainHealth #Neurodegeneration #Cholesterol #ApoE4 #ApoE4 #CognitiveHealth #Longevity #Neuroscience #MedicalResearch #DrugRepurposing #Autophagy #Amyloid #Tau #ProteinAggregation #Hexokinase #1433Protein #MetabolicHealth #PreventAlzheimers #CognitiveLongevity #Biohacking #HealthScience #StayCurious #NPC1L1 #LDL #Cardiology #Neurology #AgingResearch #AlzheimersPrevention #BrainOptimization #Pharmacology #EvidenceBased #ClinicalScience #TranslationalMedicine #WormModel #CellBiology #MechanisticMedicine #PrecisionHealth #RCT #MedicalEducation #BrainAging #Supplements #LithiumOrotate #Omega3 #LPCDHA #NAD #NMN #NicotinamideRiboside #CETP
