Uploaded November 2025 | Updated September 2026, 1 week ago
For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress & Willpower: staycuriousmetabolism.substack.com/p/how-stress-steals-your-willpower?r=40ekz2
CHAPTER
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2
Can your brain trick your body into making sugar? According to a new Nature paper, the answer is YES. In this video, Dr. Nick Norwitz MD PhD breaks down groundbreaking research showing that psychological stress can trigger the brain to send a direct neural signal to the liver, telling it to produce and release sugar into the bloodstream.
This discovery rewrites what we thought we knew about stress, blood sugar, and metabolic disease. It’s not just cortisol or other hormones driving glucose spikes — it’s a brain-liver circuit that flips genetic switches inside the liver itself, turning it into a sugar factory.
Chapters:
0:00 – Stress Makes Sugar
1:19 – New Paper in Nature: A Brain- Liver Axis
1:57 – The Value of Animal Models: Causal Mechanisms
2:40 – DREADD. An Incredibly Cool Methodology for Scientific Discovery!
4:27 – Stress Increases Blood Sugar. But HOW?!
7:04 – The Best Chapter: An Underrated Longevity Hack
8:27 – What’s Happening in the Liver with Stress?
9:34 – This Physiology and Biology are Conversed
10:20 – What Can You Do With all This?!
*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.
#Stress #Metabolism #BloodSugar #Diabetes #MetabolicHealth #LiverHealth #BrainHealth #Neuroscience #Psychology #Hormones #InsulinResistance #Type2Diabetes #Glucose #Cortisol #Adrenaline #Biology #HealthResearch #Educational #Informative #StayCurious #SugarFree #StressManagement #BreakingScience #Amygdala #PrincessBride #MindBodyConnection #MentalHealth #Neuroendocrinology #GlucoseMetabolism #ChronicStress #HealthOptimization #Longevity #Mitochondria #HumanBiology #NutritionScience #ScienceCommunication #NickNorwitz
For references and a written breakdown, see the associated Stay Curious Metabolism Newsletter: staycuriousmetabolism.substack.com/p/stress-makes-sugar-literally-this?r=40ekz2
Stress & Willpower: staycuriousmetabolism.substack.com/p/how-stress-steals-your-willpower?r=40ekz2
CHAPTER
*Call our service line at 815-STAY-CUR (815-782-9287)
*Learn more about the data, here: staycuriousmetabolism.substack.com/p/life-or-death-in-the-fine-print-the?r=40ekz2
Can your brain trick your body into making sugar? According to a new Nature paper, the answer is YES. In this video, Dr. Nick Norwitz MD PhD breaks down groundbreaking research showing that psychological stress can trigger the brain to send a direct neural signal to the liver, telling it to produce and release sugar into the bloodstream.
This discovery rewrites what we thought we knew about stress, blood sugar, and metabolic disease. It’s not just cortisol or other hormones driving glucose spikes — it’s a brain-liver circuit that flips genetic switches inside the liver itself, turning it into a sugar factory.
Chapters:
0:00 – Stress Makes Sugar
1:19 – New Paper in Nature: A Brain- Liver Axis
1:57 – The Value of Animal Models: Causal Mechanisms
2:40 – DREADD. An Incredibly Cool Methodology for Scientific Discovery!
4:27 – Stress Increases Blood Sugar. But HOW?!
7:04 – The Best Chapter: An Underrated Longevity Hack
8:27 – What’s Happening in the Liver with Stress?
9:34 – This Physiology and Biology are Conversed
10:20 – What Can You Do With all This?!
*Chapter: Chapter and its affiliates are not connected with or endorsed by any government entity or the federal Medicare program. Chapter Advisory, LLC represents Medicare Advantage HMO, PPO, and PFFS organizations and stand alone prescription drug plans that have a Medicare contract. Enrollment depends on the plan’s contract renewal. While we have a database of every Medicare plan nationwide and can help you to search among all plans, we have contracts with many but not all plans. As a result, we do not offer every plan available in your area. Currently we represent 50 organizations which offer 18,160 products nationwide. We search and recommend all plans, even those we don’t directly offer. You can contact a licensed Chapter agent to find out the number of products available in your specific area. Please contact Medicare.gov, 1-800-Medicare, or your local State Health Insurance Program (SHIP) to get information on all of your options.
#Stress #Metabolism #BloodSugar #Diabetes #MetabolicHealth #LiverHealth #BrainHealth #Neuroscience #Psychology #Hormones #InsulinResistance #Type2Diabetes #Glucose #Cortisol #Adrenaline #Biology #HealthResearch #Educational #Informative #StayCurious #SugarFree #StressManagement #BreakingScience #Amygdala #PrincessBride #MindBodyConnection #MentalHealth #Neuroendocrinology #GlucoseMetabolism #ChronicStress #HealthOptimization #Longevity #Mitochondria #HumanBiology #NutritionScience #ScienceCommunication #NickNorwitz
