Uploaded February 2026 | Updated September 2026, 2 weeks ago
If I had to choose between a statin and a PCSK9 inhibitor, I’d choose a PCSK9 inhibitor.
Statins lower LDL, but they can also worsen insulin resistance, increase Lp(a), increase diabetes risk, suppress GLP-1, interfere with mitochondrial function, and potentially contribute to muscle loss.
PCSK9 inhibitors can lower Lp(a), don't negatively imapct muscles, mitochondria or cross the blood brain barrier.
This isn’t medical advice. It’s about understanding mechanisms, side effects, and context — because cardiovascular risk isn’t a single number, and treatment shouldn’t be one-size-fits-all.
For a true deep dive and masterclass on cholesterol lowering medications, see this letter: staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2
#Cholesterol #Statins #PCSK9 #CardiovascularHealth #LpA #MetabolicHealth #InsulinResistance #GLP1 #Mitochondria #HealthScience #MedicalEducation #StayCurious
If I had to choose between a statin and a PCSK9 inhibitor, I’d choose a PCSK9 inhibitor.
Statins lower LDL, but they can also worsen insulin resistance, increase Lp(a), increase diabetes risk, suppress GLP-1, interfere with mitochondrial function, and potentially contribute to muscle loss.
PCSK9 inhibitors can lower Lp(a), don't negatively imapct muscles, mitochondria or cross the blood brain barrier.
This isn’t medical advice. It’s about understanding mechanisms, side effects, and context — because cardiovascular risk isn’t a single number, and treatment shouldn’t be one-size-fits-all.
For a true deep dive and masterclass on cholesterol lowering medications, see this letter: staycuriousmetabolism.substack.com/p/a-concise-masterclass-on-cholesterol?r=40ekz2
#Cholesterol #Statins #PCSK9 #CardiovascularHealth #LpA #MetabolicHealth #InsulinResistance #GLP1 #Mitochondria #HealthScience #MedicalEducation #StayCurious
