[Republished] U.S. Route 278: Tupelo to Oxford - Mississippi @realroadsmedia
[Republished] U.S. Route 278: Tupelo to Oxford - Mississippi  @realroadsmedia
Uploaded June 2026 | Updated September 2026, 1 week ago
🚙 Drive America's Highways for 59 miles west along U.S. Highway 278 from Tupelo to Oxford, Mississippi. 🛣️

The segment of US-278 from Tupelo to Oxford begins at the interchange with the Natchez Trace Parkway, just southwest of Tupelo. Initially traveling west as a 4-lane divided highway, the highway turns northwest to pass Trace State Park and enter Pontotoc, where it intersects MS-15 and MS-9 at full interchanges.

Continuing northwest, Route 278 crosses MS-336 before passing the south side of Thaxton and other small towns along it's northwest trek towards Oxford. At Oxford, the highway bends southwest at the intersection with MS-6 to become a by-pass around the south-side of town.
During this segment, the highway intersects several local roads at full interchanges, as well as a somewhat large interchange with Mississippi Highway 7.

Leaving Oxford, U.S. Route 278 continues west to the intersection with Mississippi Highway 113 (unsigned) where the segment of US-278 from Tupelo to Oxford ends.

---
🎵 Music: interstate411.us/music/us278-tupelo-oxford.txt

-------------
❤ If you liked this video, please help us out and click the share button to share it with all your friends.

🦸‍♂️ Express Lane Members:

YouTube Members

@raytorvalds3699
@TBKS1
@good_88

Interstate411.us Members

@pauljardis942
@lukehawk2

-------------
📹 Subscribe here (it's free!) tinyurl.com/y6fuhhta
✉ Get notified by email of new videos: tinyurl.com/i411news
💵 Join the Express Lane to get access to 4K/Real-Time videos, Ad-Free videos, and more!

⇨ Join at Interstate411.us: tinyurl.com/i411express
⇨ Join at YouTube: tinyurl.com/i411ytjoin
⇨ Join at Patreon: tinyurl.com/I411patreon

Follow us:
Website: interstate411.us
Facebook: facebook.com/interstate411
[Republished] U.S. Route 278: Tupelo to Oxford - MississippiArkansas Highway 25: Heber Springs to Greenbrier | Real Roads, Real DrivesArkansas Highway 59: Van Buren to Siloam Springs | Drive Americas Highways 🚙Interstate 40: Nashville to Knoxville, Tennessee | Real Roads, Real Drives [Remaster]U.S. Route 67: Walnut Ridge to Pocahontas | Real Roads, Real Drives [Revisited]Interstate 40: Gallup, New Mexico to Lupton, Arizona | Real Roads, Real Drives[Repost] Interstate 40: Knoxville to Lebanon - Tennessee | Rolling Through East and Middle TennesseeInterstate 70: Indianapolis to Richmond, Indiana | Real Roads, Real Drives [Revisited]Interstate 264: Eastbound in Louisville, Kentucky | Real Roads, Real Drives[Repost] Interstate 30: 30Crossing - Little Rock/North Little Rock - ArkansasU.S. Route 67: Neelyville to Poplar Bluff ~ Missouri | Real Roads, Real DrivesTennessee Route 690: Union City | Real Roads, Real Drives
RealRoads TV |

[Republished] U.S. Route 278: Tupelo to Oxford - Mississippi

SHARE TO X SHARE TO REDDIT SHARE TO FACEBOOK WALLPAPER