Uploaded January 2026 | Updated September 2026, 2 weeks ago

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Ozempic (which is the medication Semaglutide; and has different formulations known as Wegovy and Rybelsus) is a medication used to treat Type 2 Diabetes and has been used more recently for weight loss purposes. These medications are glucagon-like peptide 1 (GLP-1) receptor agonists, meaning that they “mimic” natural GLP-1 to activate these GLP-1 receptors in the brain and the gastrointestinal system to promote satiety and reduced gastric emptying. However, there has been evidence that Ozempic (and other GLP-1 receptor agonists) may cause psychological side effects, which we discuss in this lesson.

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JJ

NOTE: Most of these studies are only case studies, so not strong evidence - more research is needed to see if there is a relationship between psychological side effects and Ozempic use.

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REFERENCES:
pmc.ncbi.nlm.nih.gov/articles/PMC11208009
nature.com/articles/s41598-024-75965-2
pmc.ncbi.nlm.nih.gov/articles/PMC10669484
pubmed.ncbi.nlm.nih.gov/37706035

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