The Sheekey Science Show | My ultimate guide to senotherapeutics (senolytics vs. senomorphics) @TheSheekeyScienceShow | Uploaded May 2021 | Updated October 2024, 4 days ago.
SPONSOR - Longevity.Technology : https://www.longevity.technology/?utm_source=LT&utm_medium=youtube&utm_campaign=senotherapeutics
Senotherapeutics are therapeutics strategies that target cellular senescence. These strategies can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics) or by activating our endogenous senolytic systems (immune surveillance). But what even are senescent cells, how do senolytics work, and what current human clinical trials provide supporting data?
In this video we will begin by discussing what senescent cells are, what causes a cell to become senescent and why targeting senescent cells may provide therapeutic potential for aging and age-related diseases. We will then look at the three main branches of senotherapeutics, senolytics vs. senomorphics and what future work is being conducted to evaluate the safety and efficacy of these strategies.
So, in many ways you could consider this video my ultimate guide to senotherapeutics! :D
TIMESTAMPS;
Intro - 00:00
Senotherapeutics & senescent cells - 00:30
Senolytics - 04:20
Senomorphics - 08:00
Senolytics vs. senomorphics - 10:00
Immune surveillance - 11:55
REFERENCES;
Di Micco, R., Krizhanovsky, V., Baker, D. et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol 22, 75–95 (2021). doi.org/10.1038/s41580-020-00314-w
A versatile drug delivery system targeting senescent cells - doi.org/10.15252/emmm.201809355
Chan, A., & Narita, M. (2019). Short-term gain, long-term pain: the senescence life cycle and cancer. Genes & development, 33(3-4), 127–143. doi.org/10.1101/gad.320937.118
Check out @LifespanNews latest video -- youtube.com/watch?v=WlmkCTHy7vM
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
SPONSOR - Longevity.Technology : https://www.longevity.technology/?utm_source=LT&utm_medium=youtube&utm_campaign=senotherapeutics
Senotherapeutics are therapeutics strategies that target cellular senescence. These strategies can work by killing senescent cells (senolytics), inhibiting the proinflammatory secretory phenotype of senescent cells (senomorphics) or by activating our endogenous senolytic systems (immune surveillance). But what even are senescent cells, how do senolytics work, and what current human clinical trials provide supporting data?
In this video we will begin by discussing what senescent cells are, what causes a cell to become senescent and why targeting senescent cells may provide therapeutic potential for aging and age-related diseases. We will then look at the three main branches of senotherapeutics, senolytics vs. senomorphics and what future work is being conducted to evaluate the safety and efficacy of these strategies.
So, in many ways you could consider this video my ultimate guide to senotherapeutics! :D
TIMESTAMPS;
Intro - 00:00
Senotherapeutics & senescent cells - 00:30
Senolytics - 04:20
Senomorphics - 08:00
Senolytics vs. senomorphics - 10:00
Immune surveillance - 11:55
REFERENCES;
Di Micco, R., Krizhanovsky, V., Baker, D. et al. Cellular senescence in ageing: from mechanisms to therapeutic opportunities. Nat Rev Mol Cell Biol 22, 75–95 (2021). doi.org/10.1038/s41580-020-00314-w
A versatile drug delivery system targeting senescent cells - doi.org/10.15252/emmm.201809355
Chan, A., & Narita, M. (2019). Short-term gain, long-term pain: the senescence life cycle and cancer. Genes & development, 33(3-4), 127–143. doi.org/10.1101/gad.320937.118
Check out @LifespanNews latest video -- youtube.com/watch?v=WlmkCTHy7vM
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
