Uploaded January 2021 | Updated September 2026, 3 weeks ago
There is lot of evidence supporting calorie restriction for lifespan extension, but is this due to generic calorie depletion or due to the reduction of specific macronutrients? Many studies have already looked into protein restriction to delay aging, we'll take a look at this and a recent study that looked into the reduction of specific amino acids, branched chain amino acids, and it turns out there are sex-dependent differences... Diet is complex and it seems also age-dependent and more work will be needed, but it seems that low protein may be promising to delay aging.
TIMESTAMPS:
Intro - 00:00
Protein restriction - 01:06
Branched chain amino acids - 05:29
Study results - 06:44
My thoughts - 11:40
REFERENCES:
Richardson, N.E., Konon, E.N., Schuster, H.S. et al. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice. Nat Aging 1, 73–86 (2021). doi.org/10.1038/s43587-020-00006-2
The ratio of... doi.org/10.1016/j.cmet.2014.02.009
Low protein intake...doi.org/10.1016/j.cmet.2014.02.006
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
There is lot of evidence supporting calorie restriction for lifespan extension, but is this due to generic calorie depletion or due to the reduction of specific macronutrients? Many studies have already looked into protein restriction to delay aging, we'll take a look at this and a recent study that looked into the reduction of specific amino acids, branched chain amino acids, and it turns out there are sex-dependent differences... Diet is complex and it seems also age-dependent and more work will be needed, but it seems that low protein may be promising to delay aging.
TIMESTAMPS:
Intro - 00:00
Protein restriction - 01:06
Branched chain amino acids - 05:29
Study results - 06:44
My thoughts - 11:40
REFERENCES:
Richardson, N.E., Konon, E.N., Schuster, H.S. et al. Lifelong restriction of dietary branched-chain amino acids has sex-specific benefits for frailty and life span in mice. Nat Aging 1, 73–86 (2021). doi.org/10.1038/s43587-020-00006-2
The ratio of... doi.org/10.1016/j.cmet.2014.02.009
Low protein intake...doi.org/10.1016/j.cmet.2014.02.006
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
