Uploaded March 2021 | Updated September 2026, 3 weeks ago

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Here I had the delight in chatting to Prof David R. Liu, Professor at Harvard University, the Broad Institute, and HHMI. In the interview we discuss his interests in genome editing, how to make precise genome editing safe & efficient using the latest CRISPR tech advances in base editing and prime editing and taking it to the clinic (e.g Beam Therapeutics). Then we talk about the next frontier, epigenome editing.

To see David's publications and lab members visit his website (liugroup.us/​) or follow him on Twitter (twitter.com/davidrliu?lang=en​ )

TIMESTAMPS
Introduction - 00:00:00​
Genome editing before CRISPR - 01:05​
Using CRISPR-Cas9 - 07:00​
Base editing - 0:10:20​
Treating genetic diseases - 28:30​
Prime editing & precise genome editing - 34:30​
Cas9-SHEE (Cas9-fusions) - 54:00​
In vivo delivery of CRISPR - 56:00​
Epigenome editing & aging - 59:00​
Predictions for next 10 years - 1:04:20​

Thank you to my patreon supporters & to L-Nutra for the support in starting the interview series!

Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com