Uploaded July 2022 | Updated September 2026, 3 weeks ago
What does DNA methylation inform us about the aging process? Does the presence of absence of methyl marks merely reflect the aging process or could they be causal? What is the best way to characterise the epigenetic marks - what about considering variance and pair-wise changes of specific CpG sites? There are many unaddressed questions in the fields of epigenetics and aging - so where are we at?
In this video I spoke with Kirsten Seale about her research of the aging DNA methlyome, the approaches she takes and her thoughts on the field going forward.
Find me on Twitter - twitter.com/EleanorSheekey
Find Kirsten on Twitter - twitter.com/kirsten_blythe_
& check out her review article here; Seale, K., Horvath, S., Teschendorff, A. et al. Making sense of the ageing methylome. Nat Rev Genet (2022). doi.org/10.1038/s41576-022-00477-6
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro to epigenetics - 00:00
What is the DNA methylome - 01:15
DMPs vs. VMPs - 02:45
Primary vs. secondary aging - 04:30
Entropy - 06:30
PhD project - map of aging methylome - 08:00
Making sense of the methylome - 11:00
Future potential - 13:45
Advice for students - 14:45
Take homes & network analysis - 16:00
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
What does DNA methylation inform us about the aging process? Does the presence of absence of methyl marks merely reflect the aging process or could they be causal? What is the best way to characterise the epigenetic marks - what about considering variance and pair-wise changes of specific CpG sites? There are many unaddressed questions in the fields of epigenetics and aging - so where are we at?
In this video I spoke with Kirsten Seale about her research of the aging DNA methlyome, the approaches she takes and her thoughts on the field going forward.
Find me on Twitter - twitter.com/EleanorSheekey
Find Kirsten on Twitter - twitter.com/kirsten_blythe_
& check out her review article here; Seale, K., Horvath, S., Teschendorff, A. et al. Making sense of the ageing methylome. Nat Rev Genet (2022). doi.org/10.1038/s41576-022-00477-6
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS
Intro to epigenetics - 00:00
What is the DNA methylome - 01:15
DMPs vs. VMPs - 02:45
Primary vs. secondary aging - 04:30
Entropy - 06:30
PhD project - map of aging methylome - 08:00
Making sense of the methylome - 11:00
Future potential - 13:45
Advice for students - 14:45
Take homes & network analysis - 16:00
Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
