Uploaded January 2022 | Updated September 2026, 3 weeks ago
There are many different biomarkers that have now been used to develop so-called aging clocks that predict biological or chronological age. But one biomarker that has seen the most advances so far are epigenetic clocks that use DNA methylation as a measurement.
Currently, these tools work by using "bulk" data however this misses acquisition of heterogeneity in a dataset. But, a new publication in Nature Aging has now developed a framework for predicting age of a single cell! In this video we discuss how.
P.S I interviewed the lead author of the paper - you can view here - youtu.be/5LcgovlTxIM
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Epigenetic clocks - 00:50
Age of a single cell - 03:00
Applications of single cell age - 08:15
References:
Trapp, A., Kerepesi, C. & Gladyshev, V.N. Profiling epigenetic age in single cells. Nat Aging 1, 1189–1201 (2021). doi.org/10.1038/s43587-021-00134-3
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
There are many different biomarkers that have now been used to develop so-called aging clocks that predict biological or chronological age. But one biomarker that has seen the most advances so far are epigenetic clocks that use DNA methylation as a measurement.
Currently, these tools work by using "bulk" data however this misses acquisition of heterogeneity in a dataset. But, a new publication in Nature Aging has now developed a framework for predicting age of a single cell! In this video we discuss how.
P.S I interviewed the lead author of the paper - you can view here - youtu.be/5LcgovlTxIM
Find me on Twitter - twitter.com/EleanorSheekey
Support the channel
through PayPal - paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB
through Patreon - patreon.com/TheSheekeyScienceShow
TIMESTAMPS:
Intro - 00:00
Epigenetic clocks - 00:50
Age of a single cell - 03:00
Applications of single cell age - 08:15
References:
Trapp, A., Kerepesi, C. & Gladyshev, V.N. Profiling epigenetic age in single cells. Nat Aging 1, 1189–1201 (2021). doi.org/10.1038/s43587-021-00134-3
Icons in intro; "freepik.com/free-photos-vectors/background"Background vector created by freepik - freepik.com
