Uploaded September 2023 | Updated September 2026, 21 minutes ago
0:00 – Intro
3:08 – High-throughput full-length isoform sequencing for bulk & single-cell transcriptome
24:15 – Moving towards a resolved atlas of cell type isoforms in the human cortex
43:16 – Long-read RNA-seq of human microglia reveals novel isoforms and elucidates genetic regulation of splicing associated with Alzheimer's and Parkinson's disease
58:38 – Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of neurodevelopmental disorders
1:28:50 – Visualizing Iso-Seq data with Shiny app
1:44:16 – Single-cell isoform sequencing in neurodegenerative disease
2:00:00 – Unravelling the role of transcript expression in neurodegenerative disease: insights from long-read RNA sequencing
2:23:15 – Speaker panel discussion
In this virtual symposium, hear from a variety of researchers who are using the PacBio Iso-Seq method for bulk and single-cell transcriptomics to drive cutting-edge research in neurology, neurodegenerative diseases, and brain development. Learn about the MAS-Seq for 10x Single Cell 3’ kit and get a sneak preview of the upcoming MAS-Seq for bulk Iso-Seq kit. Discover how long-read HiFi sequencing provides extraordinary discovery power for uncovering new insights in RNA biology.
Learn more about PacBio at pacb.com
Legal & Trademarks: Visit pacb.com/legal-and-trademarks
0:00 – Intro
3:08 – High-throughput full-length isoform sequencing for bulk & single-cell transcriptome
24:15 – Moving towards a resolved atlas of cell type isoforms in the human cortex
43:16 – Long-read RNA-seq of human microglia reveals novel isoforms and elucidates genetic regulation of splicing associated with Alzheimer's and Parkinson's disease
58:38 – Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of neurodevelopmental disorders
1:28:50 – Visualizing Iso-Seq data with Shiny app
1:44:16 – Single-cell isoform sequencing in neurodegenerative disease
2:00:00 – Unravelling the role of transcript expression in neurodegenerative disease: insights from long-read RNA sequencing
2:23:15 – Speaker panel discussion
In this virtual symposium, hear from a variety of researchers who are using the PacBio Iso-Seq method for bulk and single-cell transcriptomics to drive cutting-edge research in neurology, neurodegenerative diseases, and brain development. Learn about the MAS-Seq for 10x Single Cell 3’ kit and get a sneak preview of the upcoming MAS-Seq for bulk Iso-Seq kit. Discover how long-read HiFi sequencing provides extraordinary discovery power for uncovering new insights in RNA biology.
Learn more about PacBio at pacb.com
Legal & Trademarks: Visit pacb.com/legal-and-trademarks
