Uploaded September 2025 | Updated September 2026, 2 days ago
*How can HiFi sequencing accelerate biopharma R&D?* This expert panel explores how highly accurate long-read sequencing (HiFi) from PacBio helps solve challenges in vaccine development, gene therapy, antibody discovery, and more, from target identification to quality control in research.
Experts from Pfizer, GSK, AstraZeneca, and more share their experiences. They discuss using the PacBio Revio and Vega systems for applications like full-length RNA sequencing (Iso-Seq method), AAV vector characterization, and microbial genome assembly, including plasmids, to improve research outcomes and assess product quality.
*What you’ll learn*
* Resolve complex AAV vectors and ITRs
* Characterize full-length antibody and TCR transcripts
* Assess critical quality attributes for vaccine research
* Use the targeted Iso-Seq method for therapeutic design
* Assemble microbial genomes, including plasmids, for R&D
00:00 Introduction & panelist overview
02:27 Liz Tseng: HiFi sequencing for biopharma research
05:05 Applications: Microbial WGS & plasmids
06:29 Applications: AAV & gene therapy
07:52 Applications: Full-length RNA sequencing (Iso-Seq)
10:17 Applications: Immune repertoire & antibody discovery
13:20 Panel: Jing Colatat (Pfizer) on bacterial WGS
16:48 Panel: Luigi Alvarado (GSK) on vaccine CQAs
24:03 Panel: Yang Song (AstraZeneca) on antibody screening
30:10 Panel: Balaji Olety on AAV gene therapy
35:24 Panel: Melissa Smith (ClareoBio) on immune repertoire
41:18 Panel: Emil Gustavsson (UCL) on targeted Iso-Seq
46:09 In-house vs. outsourcing sequencing
54:00 Key takeaways from each expert
Which biopharma application of HiFi sequencing is most relevant to your work? *Comment below.*
*Subscribe for more PacBio genomics content:*
youtube.com/@PacificBiosciences?sub_confirmation=1
Learn more about PacBio at pacb.com
Legal & Trademarks: pacb.com/legal-and-trademarks
For Research Use Only. Not for use in diagnostic procedures.
#HiFiSequencing #Biopharma #DrugDiscovery
*How can HiFi sequencing accelerate biopharma R&D?* This expert panel explores how highly accurate long-read sequencing (HiFi) from PacBio helps solve challenges in vaccine development, gene therapy, antibody discovery, and more, from target identification to quality control in research.
Experts from Pfizer, GSK, AstraZeneca, and more share their experiences. They discuss using the PacBio Revio and Vega systems for applications like full-length RNA sequencing (Iso-Seq method), AAV vector characterization, and microbial genome assembly, including plasmids, to improve research outcomes and assess product quality.
*What you’ll learn*
* Resolve complex AAV vectors and ITRs
* Characterize full-length antibody and TCR transcripts
* Assess critical quality attributes for vaccine research
* Use the targeted Iso-Seq method for therapeutic design
* Assemble microbial genomes, including plasmids, for R&D
00:00 Introduction & panelist overview
02:27 Liz Tseng: HiFi sequencing for biopharma research
05:05 Applications: Microbial WGS & plasmids
06:29 Applications: AAV & gene therapy
07:52 Applications: Full-length RNA sequencing (Iso-Seq)
10:17 Applications: Immune repertoire & antibody discovery
13:20 Panel: Jing Colatat (Pfizer) on bacterial WGS
16:48 Panel: Luigi Alvarado (GSK) on vaccine CQAs
24:03 Panel: Yang Song (AstraZeneca) on antibody screening
30:10 Panel: Balaji Olety on AAV gene therapy
35:24 Panel: Melissa Smith (ClareoBio) on immune repertoire
41:18 Panel: Emil Gustavsson (UCL) on targeted Iso-Seq
46:09 In-house vs. outsourcing sequencing
54:00 Key takeaways from each expert
Which biopharma application of HiFi sequencing is most relevant to your work? *Comment below.*
*Subscribe for more PacBio genomics content:*
youtube.com/@PacificBiosciences?sub_confirmation=1
Learn more about PacBio at pacb.com
Legal & Trademarks: pacb.com/legal-and-trademarks
For Research Use Only. Not for use in diagnostic procedures.
#HiFiSequencing #Biopharma #DrugDiscovery
