FoundMyFitness | Judith Campisi, Ph.D. on Cellular Senescence, Mitochondrial Dysfunction, Cancer & Aging @FoundMyFitness | Uploaded April 2017 | Updated October 2024, 8 hours ago.
Dr. Rhonda Patrick interviews Dr. Judy Campisi, a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the Aging Journal and an expert on the role of cellular senescence in the aging process and development of cancer.
Cellular senescence is so important when we discuss aging and cancer because as our cells accumulate damage, which naturally happens as we age (even as a consequence of the energy generating processes and immune cell activation), there's only so many outcomes that we can expect. The first possibility is that the cells can die. The next is that they can become senescent where they stop dividing but stay alive all-the-while secreting molecules that influence surrounding tissue… or the worst of all possible outcomes, the cells can really go off the rails and become malignant.
What's interesting is that, while accumulating senescent cells is inevitable, there are varying strategies of how to tackle senescence and this is of great interest to the field of aging. There are ways to clear out senescent cells with drugs or even dietary and lifestyle interventions.
Not only are there ways to kill senescent cells, there are also ways to influence what sort of molecules they produce, possibly limiting the inflammatory ones… even without killing them.
In this podcast, Dr. Campisi shares with us many insights on how senescence may be key to our understanding of cancer and aging.
EPISODE LINKS:
Show notes and transcript: foundmyfitness.com/episodes/judy-campisi?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Dr. Judith Campisi's Lab @ Buck: buckinstitute.org/campisiLab
PODCAST INFO:
Email: foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Apple Podcasts: podcasts.apple.com/us/podcast/foundmyfitness/id818198322?i=1000532219205
Spotify: open.spotify.com/episode/69n9HBIRRdj3XyXUufNeY2?si=U0KF4K2bRoCSlVvcdGUAjQ&nd=1
Full interview playlist: youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s
Clips playlist: youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi
Chapters:
00:00:00 - Introduction
00:00:52 - Drivers of aging
00:02:40 - Inflammation
00:08:06 - Senescence
00:18:57 - Lifespan vs healthspan
00:25:20 - Drivers of senescence
00:30:34 - Combating senescence with fasting
00:42:17 - Exercise extends lifespan
00:48:50 - Measuring senescence
00:54:45 - NAD+ boosters
00:56:00 - Fasting mimetics
00:57:00 - Cancer in animals
SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER:
Receive emailed episode notifications and regular updates on the emerging science of healthspan. foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
SUPPORT THE CHANNEL:
Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Thank you for watching!
SOCIALS:
twitter.com/foundmyfitness
facebook.com/foundmyfitness
instagram.com/foundmyfitness
PODCAST:
Apple Podcasts: podcasts.apple.com/us/podcast/foundmyfitness/id818198322
Spotify: open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d
Dr. Rhonda Patrick interviews Dr. Judy Campisi, a professor of biogerontology at the Buck Institute for Research on Aging, a co-editor in chief of the Aging Journal and an expert on the role of cellular senescence in the aging process and development of cancer.
Cellular senescence is so important when we discuss aging and cancer because as our cells accumulate damage, which naturally happens as we age (even as a consequence of the energy generating processes and immune cell activation), there's only so many outcomes that we can expect. The first possibility is that the cells can die. The next is that they can become senescent where they stop dividing but stay alive all-the-while secreting molecules that influence surrounding tissue… or the worst of all possible outcomes, the cells can really go off the rails and become malignant.
What's interesting is that, while accumulating senescent cells is inevitable, there are varying strategies of how to tackle senescence and this is of great interest to the field of aging. There are ways to clear out senescent cells with drugs or even dietary and lifestyle interventions.
Not only are there ways to kill senescent cells, there are also ways to influence what sort of molecules they produce, possibly limiting the inflammatory ones… even without killing them.
In this podcast, Dr. Campisi shares with us many insights on how senescence may be key to our understanding of cancer and aging.
EPISODE LINKS:
Show notes and transcript: foundmyfitness.com/episodes/judy-campisi?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Dr. Judith Campisi's Lab @ Buck: buckinstitute.org/campisiLab
PODCAST INFO:
Email: foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Apple Podcasts: podcasts.apple.com/us/podcast/foundmyfitness/id818198322?i=1000532219205
Spotify: open.spotify.com/episode/69n9HBIRRdj3XyXUufNeY2?si=U0KF4K2bRoCSlVvcdGUAjQ&nd=1
Full interview playlist: youtube.com/playlist?list=PLJEEAVzHu9KzgkQbe2Thh35VU-HCiId_s
Clips playlist: youtube.com/playlist?list=PLrGxo-5Uw8gI9-1IStYEvNxVukKxZBlmi
Chapters:
00:00:00 - Introduction
00:00:52 - Drivers of aging
00:02:40 - Inflammation
00:08:06 - Senescence
00:18:57 - Lifespan vs healthspan
00:25:20 - Drivers of senescence
00:30:34 - Combating senescence with fasting
00:42:17 - Exercise extends lifespan
00:48:50 - Measuring senescence
00:54:45 - NAD+ boosters
00:56:00 - Fasting mimetics
00:57:00 - Cancer in animals
SCIENCE OF HEALTHSPAN EMAIL NEWSLETTER:
Receive emailed episode notifications and regular updates on the emerging science of healthspan. foundmyfitness.com/newsletter?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
SUPPORT THE CHANNEL:
Many of the magnificent resources associated with the FoundMyFitness channel exist directly as a result of our premium membership. As a premium member, listeners get access to our exclusive podcast The Aliquot, monthly Q&As, a special summary of scientific research every other week called the Science Digest, and more. Sign up to become a premium member and nurture the existence of all of the otherwise free resources provided by FoundMyFitness at foundmyfitness.com/crowdsponsor?utm_source=youtube&utm_medium=youtube&utm_campaign=campisi_interview
Thank you for watching!
SOCIALS:
twitter.com/foundmyfitness
facebook.com/foundmyfitness
instagram.com/foundmyfitness
PODCAST:
Apple Podcasts: podcasts.apple.com/us/podcast/foundmyfitness/id818198322
Spotify: open.spotify.com/show/5QjpaU0o1Q2MkVZwwG3y7d
