Uploaded March 2026 | Updated September 2026, 2 weeks ago

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Deep dive here: open.substack.com/pub/staycuriousmetabolism/p/the-exerciseliverbrain-axis-new-science?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true

Exercise doesn’t just strengthen muscles—it may also help protect the brain. New research suggests that physical activity triggers the liver to release signaling molecules (“exerkines”) that support the integrity of the blood–brain barrier. This barrier can become more permeable with aging and in conditions like Alzheimer’s disease.
For the full mechanisms, limitations, and nuance, watch the long-form breakdown linked above.

#BloodBrainBarrier #AlzheimersResearch #ExerciseScience #BrainHealth #Neuroscience #Exerkines #StayCurious