Uploaded March 2016 | Updated September 2026, 26 minutes ago

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Ask your doctor if Enigmacil is right for you. Tell him you heard about it in a commercial filled with cartoon neurons! And that you don’t remember any of the side effects because you were distracted by a groovy dance beat!

Note: I am NOT making fun of depression or people suffering from depression. My aim is to satirize direct-to-consumer marketing of pharmaceuticals, especially antidepressants, something that isn’t allowed anywhere in the world except the U.S. and New Zealand.

Here’s the copy:

(V.O.) If you’re suffering from depression, it’s not you, it’s science. And because of science, Enigmacil may be able to help. In a clinical trial Enigmacil worked slightly better than a placebo at making people feel slightly better.

Here’s how we’ll tell you Enigmacil works: we’ll use scientific terms like neurotransmitters and reuptake inhibitors, and we’ll show you an animation of Enigmacil doing something. Wow! Look at that! That looks really effective!

And now for the fine print, here’s a non-threatening white rapper.

Disclaimer Rapper:

Enigmacil has been known to cause bleeding
Or behavior at work that may be self-defeating
You should avoid meetings and legal proceedings
You may think you’re Jesus but the thought’ll be fleeting
So, go slow if you’re toking on the greenery
Appreciate the scenery, don’t operate machinery
As far as we know your libido is finito
So you need a hobby, do Pilates, maybe try aikido

Enigmacil may weaken your bones
Give you kidney stones, and make you accident prone
It’ll give you dry mouth, make your eyes turn red
Thoughts of suicide will run through your head
So don’t go in tall buildings or walk near a river
Don’t take Enigmacil if you ever had a liver
It delivers shivers, your hands will quiver and shake, and
It all gets worse if you ever stop taking it!

V.O.
Ask your doctor if Enigmacil is right for you. And if he or she won’t say that it is, call us and we’ll find a doctor that will.

Enigmacil, it works, because we say it does.