Uploaded May 2022 | Updated September 2026, 1 week ago

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In this episode, I give a primer into pKas, and discuss the best resources for finding pKas for various compounds.

New Channel URL: youtube.com/channel/UC0nEDA3uRd5YuvBfMwQNteg/featured

In the second practice problem, I mistakenly call the Leuckart reaction the Eschweiler Clarke reaction.

Community Discord: discord.gg/QWNPETtPcZ

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Links to articles discussed in this episode:
Collection of pKa data - organicchemistrydata.org/hansreich/resources/pka
Evans pKa table - http://ccc.chem.pitt.edu/wipf/MechOMs/evans_pKa_table.pdf
Baran's book - books.apple.com/ca/book/the-portable-chemists-consultant/id618463142
Baran heterocycle poster - https://www.scripps.edu/baran/heterocycles/Essentials1-2009.pdf
N-parameter database - cup.lmu.de/oc/mayr/reaktionsdatenbank2
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I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people!

Recommended Texts:
J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations)
T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016.
LibreTexts:
chem.libretexts.org/Bookshelves/Organic_Chemistry