Uploaded April 2022 | Updated September 2026, 1 week ago

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In this episode, I discuss the Friedel-Crafts alkylation and acylation reaction, as well as introducing electron-donating and electron-withdrawing groups. I also discuss the use of a Friedel-Crafts alkylation as a method of synthesizing THC!

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Links to articles discussed in this episode:
N-parameter database - cup.lmu.de/oc/mayr/reaktionsdatenbank2
Mayr's website - cup.uni-muenchen.de/oc/mayr/DBintro.html
first Friedel-Crafts - doi.org/10.1002/adsc.201500288
second Friedel-Crafts - doi.org/10.1007/s00044-019-02299-4
Δ8-THC paper - doi.org/10.1021/acs.jnatprod.1c00567
Δ9-THC paper - doi.org/10.1021/acs.orglett.9b00198
original Δ9-THC paper - doi.org/10.1002/hlca.19690520427
HFIP alkene - doi.org/10.1021/acscatal.0c00872
HFIP epoxide - doi.org/10.1016/j.chempr.2021.10.023
first HFIP acylation - doi.org/10.1021/acs.orglett.6b01460
second HFIP acylation - doi.org/10.1021/acs.orglett.5b02851
Michael acceptor HFIP - doi.org/10.1039/C8RA01397G
first cyclopropane HFIP - doi.org/10.1039/C8SC02126K
second cyclopropane HFIP - doi.org/10.1021/acs.orglett.7b03688
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I hope you enjoyed the video! I'm planning on making a full series of videos if these videos are helpful for people!

Recommended Texts:
J. Clayden, N. Greeves, S. Warren, Organic Chemistry Second Edition, Oxford University Press, 2012. (especially good for mechanism and physical chemistry explanations)
T. W. G. Solomons, C. B. Fryle, S. A. Snyder, Organic Chemistry Twelfth Edition, Wiley-VCH Verlag GmbH & Co. KGaA, 2016.
LibreTexts:
chem.libretexts.org/Bookshelves/Organic_Chemistry