Uploaded May 2022 | Updated September 2026, 1 week ago

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In this episode, I discuss 1,2-shifts of activated amides, including Hofmann rearrangement, Curtius rearrangement, and Lossen rearrangement.

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Links to articles discussed in this episode:
practice problem paper - doi.org/10.1021/ol103050c
OG Hoffman - doi.org/10.1002/cber.188101402242
OG Curtius - doi.org/10.1002/cber.189002302232
OG Lossen - doi.org/10.1002/jlac.18721610219
1st Hofmann - doi.org/10.1002/jhet.5570180736
2nd Hofmann - doi.org/10.1002/ejoc.201500466
1st Curtius - doi.org/10.1016/j.ejmech.2017.10.025
2nd Curtius - doi.org/10.1002/anie.202004321
1st Lossen - doi.org/10.1021/acs.oprd.0c00366
2nd Lossen - doi.org/10.1016/j.tetlet.2014.12.084
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