Uploaded November 2025 | Updated September 2026, 1 week ago
In this conversation, I sit down with Professor Dom D’Agostino, one of the world’s leading experts on metabolic therapies, ketosis, and exogenous ketones. We dive deep into the science of ketone esters, MCT oils, and 1,3-butanediol, breaking down how these compounds affect the brain, liver, and mitochondria. If you’ve ever wondered what ketone supplements actually do, this interview cuts through hype with hard data, clinical context, and self-experimentation.
Mitochondrial Migration (Adapt) Video: youtu.be/R9x5Y57HuoA
0:00 – Ketones Can Rescue the Brain from Hypoglycemia
2:00 – The Self-Experiment That Changed Dom’s Career
5:00 – Ketones as a Lifeline in Severe Hypoglycemia
8:15 – Ketone Esters Explained: Forms, Effects, and Risks
16:10 – What Are MCTs and How They Boost Ketones
18:00 – The Story of MCT Oil and Alzheimer’s Disease
27:40 – Polyunsaturated Fats (PUFAs) and Ketone Production
33:00 – Ketone Salts: Benefits, Risks, and Misconceptions
36:00 – The Hidden Dangers of 1,3-Butanediol in Ketone Supplements
49:30 – Recap: Esters, MCTs, Salts, and Safety
#Ketones #Metabolism #DomDAgostino #NickNorwitz #ExogenousKetones #MCTOil #KetoDiet #MetabolicHealth #BrainHealth #LiverHealth #Neuroscience #NutritionScience #EnergyMetabolism #Mitochondria #FatMetabolism #Type2Diabetes #HealthResearch #Educational #Informative #StayCurious
In this conversation, I sit down with Professor Dom D’Agostino, one of the world’s leading experts on metabolic therapies, ketosis, and exogenous ketones. We dive deep into the science of ketone esters, MCT oils, and 1,3-butanediol, breaking down how these compounds affect the brain, liver, and mitochondria. If you’ve ever wondered what ketone supplements actually do, this interview cuts through hype with hard data, clinical context, and self-experimentation.
Mitochondrial Migration (Adapt) Video: youtu.be/R9x5Y57HuoA
0:00 – Ketones Can Rescue the Brain from Hypoglycemia
2:00 – The Self-Experiment That Changed Dom’s Career
5:00 – Ketones as a Lifeline in Severe Hypoglycemia
8:15 – Ketone Esters Explained: Forms, Effects, and Risks
16:10 – What Are MCTs and How They Boost Ketones
18:00 – The Story of MCT Oil and Alzheimer’s Disease
27:40 – Polyunsaturated Fats (PUFAs) and Ketone Production
33:00 – Ketone Salts: Benefits, Risks, and Misconceptions
36:00 – The Hidden Dangers of 1,3-Butanediol in Ketone Supplements
49:30 – Recap: Esters, MCTs, Salts, and Safety
#Ketones #Metabolism #DomDAgostino #NickNorwitz #ExogenousKetones #MCTOil #KetoDiet #MetabolicHealth #BrainHealth #LiverHealth #Neuroscience #NutritionScience #EnergyMetabolism #Mitochondria #FatMetabolism #Type2Diabetes #HealthResearch #Educational #Informative #StayCurious
