Uploaded January 2026 | Updated September 2026, 1 week ago
LINK: open.substack.com/pub/staycuriousmetabolism/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Can you have “perfect” LDL cholesterol and still have atherosclerosis?
A study in Atherosclerosis found 37% of people with very low LDL (avg ~57 mg/dL) still showed signs of plaque on imaging (CAC scan or carotid ultrasound).
This isn’t saying LDL/ApoB don’t matter — it’s that they often dominate the conversation more than they deserve, while bigger drivers of cardiovascular risk get ignored.
Read the full breakdown for the nuance that matters.
#cholesterol #ldl #apob #hearthealth #atherosclerosis #cardiovasculardisease #calciumscore #metabolichealth #insulinresistance #healthscience #evidencebased #staycurious
LINK: open.substack.com/pub/staycuriousmetabolism/p/beyond-ldl-rethinking-cardiovascular?r=40ekz2&utm_campaign=post&utm_medium=web&showWelcomeOnShare=true
Can you have “perfect” LDL cholesterol and still have atherosclerosis?
A study in Atherosclerosis found 37% of people with very low LDL (avg ~57 mg/dL) still showed signs of plaque on imaging (CAC scan or carotid ultrasound).
This isn’t saying LDL/ApoB don’t matter — it’s that they often dominate the conversation more than they deserve, while bigger drivers of cardiovascular risk get ignored.
Read the full breakdown for the nuance that matters.
#cholesterol #ldl #apob #hearthealth #atherosclerosis #cardiovasculardisease #calciumscore #metabolichealth #insulinresistance #healthscience #evidencebased #staycurious
