The Sheekey Science Show | The future of cancer therapies? - Ryan Murray @TheSheekeyScienceShow | Uploaded 10 months ago | Updated 3 hours ago
Here, I chat with Ryan Murray, a current PhD student at North Eastern University who has been using an innovative form of gene editing, called base editing, to engineer T-cells to target cancer cells. His editing approach involves making the T-cells allogeneic, more effective and stealthier!

Ryan's Twitter -
Ryan's preprint - https://www.biorxiv.org/content/10.1101/2023.08.03.551705v1.full

Find me on Twitter - https://twitter.com/EleanorSheekey

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TIMESTAMPS:
Intro - 00:00
Engineering CAR T cells - 01:00
Next steps - 28:00

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

Icons in intro; "https://www.freepik.com/free-photos-vectors/background"Background vector created by freepik - www.freepik.com

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$Follistatin - why is this the new longevity trend? Muscle loss, also known as sarcopenia, is a natural part of aging that occurs due to various factors, such as reduced physical activity, hormonal changes, and protein deficiency. Muscle loss can lead to weakness, mobility problems, falls, fractures, and increased risk of chronic diseases. There are also various genetic diseases that result in muscle loss and reduced function and hence much research has been conducted to find therapeutic solutions focusing on myostatin and follistatin. Well take a look at a mouse study that saw longevity benefits following follistatin gene therapy and some clinical trials in development. Find me on Twitter - https://twitter.com/EleanorSheekey Support the channel through PayPal - https://paypal.me/sheekeyscience?country.x=GB&locale.x=en_GB through Patreon - https://www.patreon.com/TheSheekeyScienceShow TIMESTAMPS Intro - 00:00 Myostatin - 00:55 Follistatin - 02:11 References: McPherron, A., Lawler, A. & Lee, SJ. Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member. *Nature* **387**, 83–90 (1997). https://doi-org.ezp.lib.cam.ac.uk/10.1038/387083a0 New intranasal and injectable gene therapy for healthy life extension - https://doi.org/10.1073/pnas.2121499119 Follistatin-induced muscle hypertrophy in aged mice improves neuromuscular junction innervation and function - https://doi.org/10.1016/j.neurobiolaging.2021.03.005 Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates - https://doi.org/10.1126/scitranslmed.3000112 Please note that The Sheekey Science Show is distinct from Eleanor Sheekeys teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.$

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